Department of Microbiology, K.G. Medical University, Lucknow, India.
Former Vice-Chancellor, K.G. Medical University, Lucknow, India.
Indian J Med Res. 2018 Mar;147(3):239-247. doi: 10.4103/ijmr.IJMR_1816_16.
Erythrovirus B19 (B19V) is one of the erythroviruses known to be pathogenic in humans. B19V is classified into three distinct genotypes; 1, 2 and 3, differing from each other by 2-13 per cent. Genotype 1 consists of the prototype B19V isolates, genotype 2 comprises the A6, LaLi and their related isolates while genotype 3 includes the V9- and V9-related isolates. The classification of genotype 1 into two subtypes (1A and 1B) and genotype 3 into two subtypes (3a and 3b) with an estimated nucleotide difference of about 5 per cent has been done. Predominance of genotype 1 across all the continents is seen followed by genotypes 2 and 3. There are no disease-specific genotypes. All the three genotypes have been found in symptomatic as well as asymptomatic individuals and have been reported from several countries across the world. The prevalence of genotype 2 in older populations and its absence from current circulation in Northern Europe has also been reported. The present review focuses on geographic distribution and association of genotypes of B19V with different clinical manifestations.
人类细小病毒 B19（B19V）是已知具有致病性的红病毒之一。B19V 分为三个不同的基因型；1、2 和 3，彼此之间差异为 2-13%。基因型 1 由原型 B19V 分离株组成，基因型 2 包括 A6、LaLi 及其相关分离株，而基因型 3 包括 V9-和 V9 相关分离株。已经对基因型 1 进行了分类为两个亚型（1A 和 1B）和基因型 3 分为两个亚型（3a 和 3b），估计核苷酸差异约为 5%。在所有大陆都看到基因型 1 的优势，其次是基因型 2 和 3。没有特定疾病的基因型。所有三种基因型都在有症状和无症状个体中被发现，并在世界各地的几个国家都有报道。也报道了基因型 2 在老年人群中的流行以及在北欧当前循环中的缺失。本综述重点关注 B19V 基因型的地理分布和与不同临床表现的关联。
