Masood Sadia, Sajid Sara, Jafferani Asif, Tabassum Saadia, Ansar Sobia
Department of Medicine, Faculty Office Building, Aga Khan University Hospital, Karachi, Pakistan.
Oman Med J. 2014 Mar;29(2):130-1. doi: 10.5001/omj.2014.31.
Autoimmune diseases are known to have association with each other but it is very rare to see multiple autoimmune diseases in one patient. The combination of at least three autoimmune diseases in the same patient is referred to as multiple autoimmune syndrome. The case we are reporting features multiple autoimmune syndrome with five different conditions. The patient had type 1 diabetes mellitus, autoimmune hemolytic anemia, systemic lupus erythematosus, vitiligo, and psoriasis. Psoriasis has rarely been reported previously under the spectrum of autoimmune syndrome. Although the relationship of autoimmune conditions with each other has been explored in the past, this case adds yet another dimension to the unique evolution of autoimmune pathologies. The patient presented with a combination of five autoimmune diseases, which makes it consistent type three multiple autoimmune syndromes with the addition of psoriasis. The current case is unique in this aspect that the combination of these five autoimmune disorders has never been reported in the past.
自身免疫性疾病之间相互关联已为人所知，但在同一患者身上出现多种自身免疫性疾病的情况极为罕见。同一患者身上至少合并三种自身免疫性疾病被称为多发性自身免疫综合征。我们报告的这例病例呈现出五种不同病症的多发性自身免疫综合征。该患者患有1型糖尿病、自身免疫性溶血性贫血、系统性红斑狼疮、白癜风和银屑病。银屑病此前在自身免疫综合征范围内鲜有报道。尽管过去已对自身免疫性病症之间的关系进行过探究，但该病例为自身免疫性病理的独特演变增添了新的维度。该患者同时患有五种自身免疫性疾病，这使其符合伴有银屑病的Ⅲ型多发性自身免疫综合征。就这方面而言，目前这例病例很独特，因为这五种自身免疫性疾病的组合过去从未有过报道。
