Lee Sul Hee, Kim Ye Seul, Kim Hyun Ju, Park Young Lip
Department of Dermatology, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
Uljin Medical Center, Uljin, Korea.
Ann Dermatol. 2017 Dec;29(6):782-785. doi: 10.5021/ad.2017.29.6.782. Epub 2017 Oct 30.
Multiple autoimmune syndrome (MAS) is a rare condition, in which at least three well-defined autoimmune diseases co-occur in a single patient. Although the pathogenesis of MAS remains poorly understood, genetic, immunological, hormonal, and environmental factors may all play a role. Although three classic subtypes of MAS are well known, several cases that could not be placed into any of these three categories have recently been reported. To the best of our knowledge, the co-existence of psoriasis, vitiligo, and Crohn's disease has been reported in only one patient, who had a total of five autoimmune diseases (alopecia areata and oral lichen planus in addition to the three conditions mentioned). We herein describe a rare case of MAS presenting with psoriasis, vitiligo, and Crohn's disease, and suggest that tumor necrosis factor-α may be associated with the pathogenesis of all three conditions.
多重自身免疫综合征（MAS）是一种罕见疾病，指单一患者同时出现至少三种明确的自身免疫性疾病。尽管MAS的发病机制仍知之甚少，但遗传、免疫、激素和环境因素可能均起作用。虽然MAS的三种经典亚型广为人知，但最近有报道称，有几例病例无法归入这三类中的任何一类。据我们所知，银屑病、白癜风和克罗恩病共存的情况仅在一名患者中被报道过，该患者共有五种自身免疫性疾病（除上述三种疾病外，还有斑秃和口腔扁平苔藓）。我们在此描述一例罕见的MAS病例，其表现为银屑病、白癜风和克罗恩病，并提示肿瘤坏死因子-α可能与这三种疾病的发病机制均相关。
