针对希腊山羊 Q211、S146 和 K222 角蛋白 PRNP 等位基因的羊痒病抗性育种方案的观点。
Perspectives of a scrapie resistance breeding scheme targeting Q211, S146 and K222 caprine PRNP alleles in Greek goats.
机构信息
Department of Pharmaceutical Sciences, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
出版信息
Vet Res. 2014 Apr 9;45(1):43. doi: 10.1186/1297-9716-45-43.
Abstract
The present study investigates the potential use of the scrapie-protective Q211 S146 and K222 caprine PRNP alleles as targets for selective breeding in Greek goats. Genotyping data from a high number of healthy goats with special emphasis on bucks, revealed high frequencies of these alleles, while the estimated probabilities of disease occurrence in animals carrying these alleles were low, suggesting that they can be used for selection. Greek goats represent one of the largest populations in Europe. Thus, the considerations presented here are an example of the expected effect of such a scheme on scrapie occurrence and on stakeholders.
摘要
本研究调查了利用 Q211S146 和 K222 两种羊朊病毒蛋白抗性等位基因作为选择性繁殖目标在希腊山羊中的潜在应用。对大量健康山羊（尤其是公山羊）的基因分型数据进行了特别强调，结果表明这些等位基因的频率很高，而携带这些等位基因的动物患病的估计概率很低，这表明它们可以用于选择。希腊山羊是欧洲最大的山羊种群之一。因此，这里提出的考虑因素是这种方案对羊瘙痒病发生和利益相关者的预期影响的一个例子。
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