Rostami Elham, Kashanian Soheila, Azandaryani Abbas H, Faramarzi Hossain, Dolatabadi Jafar Ezzati Nazhad, Omidfar Kobra
Larestan School of Medical Science, Larestan, Iran.
Faculty of Chemistry, Nanoscience and Nanotechnology Research Center and Sensor and Biosensor Research Center, Razi University, P.O. Box 67149, Kermanshah, Iran.
Chem Phys Lipids. 2014 Jul;181:56-61. doi: 10.1016/j.chemphyslip.2014.03.006. Epub 2014 Apr 6.
The present review aims to show the features of solid lipid nanoparticles (SLNs) which are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery and research. Because of some unique features of SLNs such as their unique size dependent properties it offers possibility to develop new therapeutics. A common denominator of all these SLN-based platforms is to deliver drugs into specific tissues or cells in a pathological setting with minimal adverse effects on bystander cells. SLNs are capable to incorporate drugs into nanocarriers which lead to a new prototype in drug delivery which maybe used for drug targeting. Hence solid lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence attracted wide attention of researchers. This review presents a broad treatment of targeted solid lipid nanoparticles discussing their types such as antibody SLN, magnetic SLN, pH sensitive SLN and cationic SLN.
本综述旨在展示固体脂质纳米粒（SLNs）的特性，其处于快速发展的纳米技术领域前沿，在药物递送和研究中有多种潜在应用。由于SLNs具有一些独特特性，如独特的尺寸依赖性性质，它为开发新疗法提供了可能性。所有这些基于SLN的平台的一个共同特点是，在病理环境下将药物递送至特定组织或细胞，同时对旁观者细胞产生最小的不良影响。SLNs能够将药物纳入纳米载体，这导致了药物递送中的一种新原型，可用于药物靶向。因此，固体脂质纳米粒在实现可控和位点特异性药物递送目标方面具有巨大潜力，从而吸引了研究人员的广泛关注。本综述广泛探讨了靶向固体脂质纳米粒，讨论了它们的类型，如抗体SLN、磁性SLN、pH敏感SLN和阳离子SLN。
