Asadi Mohammad Hossein, Zafari Fariba, Sarveazad Arash, Abbasi Mehdi, Safa Majid, Koruji Morteza, Yari Abazar, Alizadeh Miran Rafieh
Department of Anatomy, School of Medicine, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, IR Iran.
Nephrourol Mon. 2013 Nov 4;6(1):e12125. doi: 10.5812/numonthly.12125. eCollection 2014 Jan.
Cadmium (Cd) is known to cause various disorders in the testis. The general population may be exposed to Cd through ingestion of food and drinking water, inhalation of particulates from ambient air, tobacco smoke and ingestion of contaminated soil and dust. Saffron (Crocus sativus L.) is widely used as a food flavour, and has well known medicinal effects.
The aim of this study was to determine the effects of saffron on the results of semen parameters (sperm concentration, motility and viability in cauda of epididymis) in rats exposed to cadmium.
Thirty Wistar male rats were divided into four groups. Cadmium chloride (1 mg/kg body weight) was injected intraperitoneally during 16 days at intervals of 48 hours between subsequent treatments. Crocus sativus L. (100 mg/kg b.w., IP) was pretreated in both control and cadmium-injected rats. Both control and cadmium-injected rats were pretreated with Crocus sativus L. (100 mg/kg b.w., IP). The animals were killed and their sperm count, motility, and vitality were evaluated.
Sperm parameters did not differ significantly between control and sham groups. Following contamination with cadmium, sperm count, motility and vitality were significantly decreased in comparison to control group (P < 0.05). In pretreated (saffron) group, the sperm parameters improved significantly in comparison with cadmium group (P ≤ 0.05). A significant decrease in sperm motility was observed in Cd-treated rats compared to the control rats. However, no significant changes were recorded by comparison of the control and saffron treated groups except for the sperm motility parameter.
Saffron, as an antioxidant, is positively effective on sperm parameters in rats exposed with cadmium.
已知镉（Cd）会导致睾丸出现各种病症。普通人群可能通过摄入食物和饮用水、吸入环境空气中的颗粒物、烟草烟雾以及摄入受污染的土壤和灰尘而接触到镉。藏红花（番红花）被广泛用作食品香料，并且具有众所周知的药用功效。
本研究的目的是确定藏红花对镉暴露大鼠精液参数（附睾尾部精子浓度、活力和存活率）结果的影响。
将30只雄性Wistar大鼠分为四组。在16天内每隔48小时腹腔注射氯化镉（1毫克/千克体重）。对照组和注射镉的大鼠均预先给予藏红花（100毫克/千克体重，腹腔注射）。处死动物后，评估其精子数量、活力和存活率。
对照组和假手术组之间的精子参数无显著差异。与对照组相比，镉污染后精子数量、活力和存活率显著降低（P < 0.05）。在预先处理（藏红花）组中，与镉组相比精子参数显著改善（P≤0.05）。与对照大鼠相比，镉处理的大鼠精子活力显著降低。然而，除精子活力参数外，对照组和藏红花处理组之间比较未记录到显著变化。
藏红花作为一种抗氧化剂，对镉暴露大鼠的精子参数有积极影响。
