Manev H, Pericić D, Mück-Seler D
Department of Experimental Biology and Medicine, Ruder Bosković Institute, Zagreb, Yugoslavia.
Pharmacol Biochem Behav. 1989 Jan;32(1):111-5. doi: 10.1016/0091-3057(89)90218-9.
Fifty mg/kg of ergot alkaloid dihydroergosine (DHESN) inhibited the mouse-killing behavior of isolated male rats, while 10 mg/kg did not. This effect of DHESN (50 mg/kg) lasted for 24 hr. When an additional injection of DHESN (50 mg/kg) was given to mouse-killer rats 6 days following the first, the mouse-killing behavior was again inhibited. The effect of the second drug injection also persisted for 24 hr and was accompanied by an increased concentration of 5-HT in the raphe nuclei and hypothalamus and by a decreased concentration of GABA in the olfactory bulbs. DHESN also inhibited aggressiveness in isolated mice. Two hr following the administration of 10 mg/kg DHESN the fighting was inhibited in 46% of pairs tested, while 50 mg/kg abolished it completely. The effect of 50 mg/kg lasted 24 hr. These results, showing the antiaggressive effects of DHESN, support our previous suggestion that DHESN might presumably be a new antidepressant, and suggest that besides the serotoninergic, the GABA-ergic system might also be involved in the modification of behavior induced by this drug.
50毫克/千克的麦角生物碱二氢麦角隐亭（DHESN）可抑制隔离的雄性大鼠的杀鼠行为，而10毫克/千克则无此作用。DHESN（50毫克/千克）的这种作用持续24小时。在首次给药6天后，对杀鼠大鼠再次注射DHESN（50毫克/千克），杀鼠行为再次受到抑制。第二次药物注射的作用也持续24小时，同时中缝核和下丘脑5-羟色胺（5-HT）浓度升高，嗅球中γ-氨基丁酸（GABA）浓度降低。DHESN还可抑制隔离小鼠的攻击性。给予10毫克/千克DHESN两小时后，46%的受试小鼠对打斗行为受到抑制，而50毫克/千克则可完全消除打斗行为。50毫克/千克的作用持续24小时。这些显示DHESN具有抗攻击作用的结果，支持了我们之前的推测，即DHESN可能是一种新型抗抑郁药，并表明除了5-羟色胺能系统外，GABA能系统可能也参与了该药物诱导的行为改变。
