Manev H, Pericic D
Department of Experimental Biology and Medicine, Rudjer Boskovic Institute, Zagreb, Yugoslavia.
Psychoneuroendocrinology. 1988;13(6):465-9. doi: 10.1016/0306-4530(88)90031-5.
The potential antidepressant properties of the ergot alkaloid dihydroergosine (DHESN) were studied in rats forced to swim in a restricted space. DHESN (50 mg/kg, intraperitoneally) reduced the duration of immobility in rats forced to swim 1 hr after administration. This effect was still present after 48 hr, but 7 hr. In non-swimming rats, the same dose of DHESN increased the plasma corticosterone concentration when administered 1 hr prior to sacrifice, but was without effect 48 hr after administration. In rats forced to swim, DHESN elicited two opposite effects. One hr following a single administration, it increased plasma secretion of corticosterone, whereas administered 48 hr prior to forced swimming, it decreased plasma corticosterone. These results, along with our previous data, give evidence that DHESN might possess antidepressant properties.
在被迫在受限空间游泳的大鼠中研究了麦角生物碱二氢麦角隐亭（DHESN）的潜在抗抑郁特性。DHESN（50毫克/千克，腹腔注射）可缩短给药1小时后被迫游泳大鼠的不动时间。48小时后此效应仍存在，但7小时后不存在。在未游泳的大鼠中，相同剂量的DHESN在处死前1小时给药会增加血浆皮质酮浓度，但给药48小时后无此作用。在被迫游泳的大鼠中，DHESN产生两种相反的效应。单次给药1小时后，它会增加皮质酮的血浆分泌，而在被迫游泳前48小时给药，则会降低血浆皮质酮水平。这些结果以及我们之前的数据表明，DHESN可能具有抗抑郁特性。
