Fukuma N, McLachlan S M, Petersen V B, Kau P, Bradbury J, Devey M, Bleasdale K, Grabowski P, Smith B R
Department of Medicine, University of Wales College of Medicine, Cardiff, U.K.
Immunology. 1989 May;67(1):129-31.
IgG autoantibodies to thyroglobulin (Tg) in the serum of patients with autoimmune thyroid disease only recognize a very limited number of epitopes, probably between four and six (Nye, Pontes De Carvalho & Roitt, 1980) on the large Tg molecule (660,000 MW), but attempts to characterize the epitopes have been unsuccessful so far (Male et al., 1985). The distribution of Tg autoantibodies between the IgG subclasses also tends to be restricted and individual patients possess characteristic 'fingerprints' of high affinity IgG1 and/or IgG4 Tg antibodies with smaller amounts of IgG2 Tg antibody (McLachlan et al., 1987, 1988). We have therefore investigated the possibility that Tg autoantibodies of different IgG subclasses interact with different epitopes on Tg.
自身免疫性甲状腺疾病患者血清中针对甲状腺球蛋白(Tg)的IgG自身抗体仅识别大Tg分子(660,000 MW)上非常有限数量的表位,可能在4至6个之间(Nye、Pontes De Carvalho和Roitt,1980年),但迄今为止,对这些表位进行表征的尝试均未成功(Male等人,1985年)。Tg自身抗体在IgG亚类之间的分布也往往受到限制,个体患者具有高亲和力IgG1和/或IgG4 Tg抗体以及少量IgG2 Tg抗体的特征性“指纹”(McLachlan等人,1987年、1988年)。因此,我们研究了不同IgG亚类的Tg自身抗体与Tg上不同表位相互作用的可能性。