Biomedical Optics Research Laboratory, Division of Neonatology, University Hospital Zurich, Frauenklinikstasse 10, 8091, Zurich, Switzerland.
Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland.
Adv Exp Med Biol. 2014;812:279-285. doi: 10.1007/978-1-4939-0620-8_37.
In adults, cerebral oxy-([O₂Hb]) and deoxyhemoglobin concentrations ([HHb]) change characteristically at transitions of sleep stages. The aims were to assess these changes in adolescents and additionally to measure tissue oxygen saturation (StO₂) by near infrared spectroscopy (NIRS). Previously it was reported that in adults [O₂Hb] increased and [HHb] decreased at the transition from non-rapid eye movement sleep (NREMS) to REMS and wakefulness. Transitions to NREMS from REMS/wakefulness led to a decrease in [O₂Hb] and an increase in [HHb]. We measured [O₂Hb], [HHb] and tissue oxygenation (StO₂) with NIRS approximately above the left prefrontal cortex in 12 healthy adolescent males (aged 10-16 years). We found comparable signs and magnitudes of changes in [O₂Hb] and [HHb] as observed in adults. StO₂ increased at the transitions from NREMS to REMS and decreased from REMS to NREMS and at sleep onset (all p < 0.01, linear mixed effects model). Changes in oxygen metabolism during sleep transitions are similar in adolescents and adults. In addition, we show for the first time temporal changes of StO₂ at sleep transitions.
在成年人中，睡眠阶段转换时大脑氧合血红蛋白（[O₂Hb]）和脱氧血红蛋白浓度（[HHb]）会发生特征性变化。本研究旨在评估青少年的这些变化，并通过近红外光谱（NIRS）测量组织氧饱和度（StO₂）。此前有研究报道，成年人在从非快速眼动睡眠（NREMS）到 REM 和觉醒的转换过程中，[O₂Hb]增加，[HHb]减少。从 REM/Wakefulness 到 NREMS 的转换导致 [O₂Hb]减少和 [HHb]增加。我们使用 NIRS 测量了 12 名健康青少年男性（年龄 10-16 岁）左侧前额叶皮层上方的[O₂Hb]、[HHb]和组织氧合（StO₂）。我们发现[O₂Hb]和[HHb]的变化与成年人观察到的相似。NREMS 向 REM 转变时 StO₂增加，从 REM 向 NREMS 转变和睡眠开始时 StO₂减少（均 p<0.01，线性混合效应模型）。睡眠转换期间的氧代谢变化在青少年和成年人中相似。此外，我们首次显示了 StO₂ 在睡眠转换期间的时间变化。
