Sista Prakash, Ghosh Koushik, Martinez Jennifer S, Rocha Reginaldo C
J Nanosci Nanotechnol. 2014 Jan;14(1):250-72. doi: 10.1166/jnn.2014.9111.
Polythiophene and its derivatives have shown tremendous potential for interfacing electrically conducting polymers with biological applications. These semiconducting organic polymers are relatively soft, conduct electrons and ions, have low cytotoxicity, and can undergo facile chemical modifications. In addition, the reduction in electrical impedance of electrodes coated with polythiophenes may prove to be invaluable for a stable and permanent connection between devices and biological tissues. This review article focuses on the synthesis and some key applications of polythiophenes in multidisciplinary areas at the interface with biology. These polymers have shown tremendous potential in biological applications such as diagnostics, therapy, drug delivery, imaging, implant devices and artificial organs.
聚噻吩及其衍生物在将导电聚合物与生物应用相结合方面显示出巨大潜力。这些半导体有机聚合物相对较软，能传导电子和离子，具有低细胞毒性，并且可以进行简便的化学修饰。此外，涂有聚噻吩的电极的电阻抗降低对于设备与生物组织之间稳定且持久的连接可能具有不可估量的价值。这篇综述文章聚焦于聚噻吩在与生物学交叉的多学科领域中的合成及一些关键应用。这些聚合物在诊断、治疗、药物递送、成像、植入设备和人工器官等生物应用中已显示出巨大潜力。
