Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei City 10617, Taiwan.
Nanomaterials and Polymer Nanocomposites Laboratory, School of Engineering, University of British Columbia, Kelowna, BC V1V 1V7, Canada.
Int J Mol Sci. 2021 Jun 25;22(13):6850. doi: 10.3390/ijms22136850.
In this review, the unique properties of intrinsically conducting polymer (ICP) in biomedical engineering fields are summarized. Polythiophene and its valuable derivatives are known as potent materials that can broadly be applied in biosensors, DNA, and gene delivery applications. Moreover, this material plays a basic role in curing and promoting anti-HIV drugs. Some of the thiophene's derivatives were chosen for different experiments and investigations to study their behavior and effects while binding with different materials and establishing new compounds. Many methods were considered for electrode coating and the conversion of thiophene to different monomers to improve their functions and to use them for a new generation of novel medical usages. It is believed that polythiophenes and their derivatives can be used in the future as a substitute for many old-fashioned ways of creating chemical biosensors polymeric materials and also drugs with lower side effects yet having a more effective response. It can be noted that syncing biochemistry with biomedical engineering will lead to a new generation of science, especially one that involves high-efficiency polymers. Therefore, since polythiophene can be customized with many derivatives, some of the novel combinations are covered in this review.
在这篇综述中，总结了本征导电聚合物（ICP）在生物医学工程领域的独特性质。聚噻吩及其有价值的衍生物是一种有效的材料，可以广泛应用于生物传感器、DNA 和基因传递应用。此外，这种材料在治疗和促进抗 HIV 药物方面发挥着基本作用。选择了噻吩的一些衍生物进行不同的实验和研究，以研究它们在与不同材料结合和建立新化合物时的行为和作用。考虑了许多方法来进行电极涂层，以及将噻吩转化为不同的单体，以提高它们的功能，并将它们用于新一代新型医疗用途。人们相信，聚噻吩及其衍生物将来可以替代许多老式的化学生物传感器聚合材料的制造方法，以及副作用更低但反应更有效的药物。值得注意的是，将生物化学与生物医学工程同步将产生新一代的科学，特别是涉及高效聚合物的科学。因此，由于聚噻吩可以用许多衍生物进行定制，因此本综述涵盖了一些新的组合。
