Wang Cheng, Liu Biao, Lu Jun, Zhang Ge, Lu Aiping
J Nanosci Nanotechnol. 2014 Jan;14(1):501-12. doi: 10.1166/jnn.2014.8746.
Cell-specific delivery of active agents for treatment of human disease is a long cherished object for scientific researchers. Nanoscience generated nanosized carriers, such as liposome, micelle and nanoparticle, provides potential to realize such purpose based on the nanometer size effect (< 1000 nm), however, the sole nanocarrier with no specific ligands are not sufficient to deliver drugs to target sites. Aptamers are single-stranded oligonucleotides which can specifically recognize and bind to target cells by distinct secondary and tertiary structures even without knowledge of characteristic protein profiles on cell surface. Thus, aptamer, as a target moiety, provides a potential approach to realize pathological site-specific delivery of active agents. This review highlighted the strategies for combination of aptamer and targeted drug delivery, further summarized their preparation methods, strengths and weaknesses to facilitate the development of targeted drug delivery system.
用于治疗人类疾病的活性药物的细胞特异性递送一直是科研人员长期以来梦寐以求的目标。纳米科学产生了纳米级载体，如脂质体、胶束和纳米颗粒，基于纳米尺寸效应（<1000 nm）为实现这一目标提供了潜力，然而，没有特异性配体的单一纳米载体不足以将药物递送至靶位点。适配体是单链寡核苷酸，即使不了解细胞表面特征性蛋白质概况，也能通过独特的二级和三级结构特异性识别并结合靶细胞。因此，适配体作为一种靶向部分，为实现活性药物的病理部位特异性递送提供了一种潜在方法。本文综述重点介绍了适配体与靶向药物递送相结合的策略，进一步总结了它们的制备方法、优缺点，以促进靶向药物递送系统的发展。
