Fosen Katina M, Thom Stephen R
1 Department of Emergency Medicine, Institute for Environmental Medicine, University of Pennsylvania Medical Center , Philadelphia, Pennsylvania.
Antioxid Redox Signal. 2014 Oct 10;21(11):1634-47. doi: 10.1089/ars.2014.5940. Epub 2014 May 19.
Oxidative stress is recognized as playing a role in stem cell mobilization from peripheral sites and also cell function.
This review focuses on the impact of hyperoxia on vasculogenic stem cells and elements of wound healing.
Components of the wound-healing process in which oxidative stress has a positive impact on the various cells involved in wound healing are highlighted. A slightly different view of wound-healing physiology is adopted by departing from the often used notion of sequential stages: hemostatic, inflammatory, proliferative, and remodeling and instead organizes the cascade of wound healing as overlapping events or waves pertaining to reactive oxygen species, lactate, and nitric oxide. This was done because hyperoxia has effects of a number of cell signaling events that converge to influence cell recruitment/chemotaxis and gene regulation/protein synthesis responses which mediate wound healing.
Our alternative perspective of the stages of wound healing eases recognition of the multiple sites where oxidative stress has an impact on wound healing. This aids the focus on mechanistic events and the interplay among various cell types and biochemical processes. It also highlights the areas where additional research is needed.
氧化应激被认为在外周部位的干细胞动员以及细胞功能方面发挥作用。
本综述聚焦于高氧对血管生成干细胞及伤口愈合要素的影响。
强调了氧化应激对伤口愈合过程中涉及的各种细胞具有积极影响的伤口愈合过程组成部分。通过摒弃常用的止血、炎症、增殖和重塑等相继阶段的概念，采用了一种略有不同的伤口愈合生理学观点，而是将伤口愈合级联组织为与活性氧、乳酸和一氧化氮相关的重叠事件或波。这样做是因为高氧对许多细胞信号事件有影响，这些事件共同影响细胞募集/趋化作用以及介导伤口愈合的基因调控/蛋白质合成反应。
我们对伤口愈合阶段的另一种观点有助于识别氧化应激对伤口愈合产生影响的多个部位。这有助于聚焦于机制性事件以及各种细胞类型和生化过程之间的相互作用。它还突出了需要进一步研究的领域。
