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肯尼亚的国家层面的结核病和艾滋病毒:来自肯尼亚第二次艾滋病指标调查的结果。

Tuberculosis and HIV at the national level in Kenya: results from the Second Kenya AIDS Indicator Survey.

机构信息

*National AIDS and Sexually Transmitted Infection (STI) Control Programme, Ministry of Health, Nairobi, Kenya; †Divison of Global HIV/AIDS, Center for Global health, US Centers for Disease Control and Prevention, Nairobi, Kenya; and ‡Global Health Sciences, University of California, San Francisco, San Francisco, CA.

出版信息

J Acquir Immune Defic Syndr. 2014 May 1;66 Suppl 1(Suppl 1):S106-15. doi: 10.1097/QAI.0000000000000120.

Abstract

BACKGROUND

Co-morbidity with tuberculosis and HIV is a common cause of mortality in sub-Saharan Africa. In the second Kenya AIDS Indicator Survey, we collected data on knowledge and experience of HIV and tuberculosis, as well as on access to and coverage of relevant treatment services and antiretroviral therapy (ART) in Kenya.

METHODS

A national, population-based household survey was conducted from October 2012 to February 2013. Information was collected through household questionnaires, and blood samples were taken for HIV, CD4 cell counts, and HIV viral load testing at a central laboratory.

RESULTS

Overall, 13,720 persons aged 15-64 years participated; 96.7% [95% confidence interval (CI): 96.3 to 97.1] had heard of tuberculosis, of whom 2.0% (95% CI: 1.7 to 2.2) reported having prior tuberculosis. Among those with laboratory-confirmed HIV infection, 11.6% (95% CI: 8.9 to 14.3) reported prior tuberculosis. The prevalence of laboratory-confirmed HIV infection in persons reporting prior tuberculosis was 33.2% (95% CI: 26.2 to 40.2) compared to 5.1% (95% CI: 4.5 to 5.8) in persons without prior tuberculosis. Among those in care, coverage of ART for treatment-eligible persons was 100% for those with prior tuberculosis and 88.6% (95% CI: 81.6 to 95.7) for those without. Among all HIV-infected persons, ART coverage among treatment-eligible persons was 86.9% (95% CI: 74.2 to 99.5) for persons with prior tuberculosis and 58.3% (95% CI: 47.6 to 69.0) for those without.

CONCLUSIONS

Morbidity from tuberculosis and HIV remain major health challenges in Kenya. Tuberculosis is an important entry point for HIV diagnosis and treatment. Lack of knowledge of HIV serostatus is an obstacle to access to HIV services and timely ART for prevention of HIV transmission and HIV-associated disease, including tuberculosis.

摘要

背景

在撒哈拉以南非洲,结核病和艾滋病合并感染是导致死亡的常见原因。在肯尼亚第二次艾滋病指标调查中,我们收集了肯尼亚有关艾滋病和结核病知识与经验、以及获得和利用相关治疗服务和抗逆转录病毒疗法(ART)的情况数据。

方法

2012 年 10 月至 2013 年 2 月进行了全国性的基于人群的家庭调查。通过家庭问卷收集信息,并在中央实验室采集血样进行 HIV、CD4 细胞计数和 HIV 病毒载量检测。

结果

共有 13720 名 15-64 岁的人参与了这项研究;96.7%(95%置信区间:96.3-97.1)听说过结核病,其中 2.0%(95%置信区间:1.7-2.2)报告曾患有结核病。在实验室确诊的 HIV 感染者中,11.6%(95%置信区间:8.9-14.3)报告曾患有结核病。曾患有结核病的人群中实验室确诊 HIV 感染的患病率为 33.2%(95%置信区间:26.2-40.2),而未患结核病的人群中这一比例为 5.1%(95%置信区间:4.5-5.8)。在接受治疗的人群中,曾患有结核病的患者获得抗逆转录病毒治疗的 ART 覆盖率为 100%,而未患有结核病的患者的 ART 覆盖率为 88.6%(95%置信区间:81.6-95.7)。在所有 HIV 感染者中,曾患有结核病的患者获得治疗的 ART 覆盖率为 86.9%(95%置信区间:74.2-99.5),而未患有结核病的患者的 ART 覆盖率为 58.3%(95%置信区间:47.6-69.0)。

结论

结核病和艾滋病导致的发病率仍是肯尼亚面临的重大健康挑战。结核病是 HIV 诊断和治疗的重要切入点。缺乏对 HIV 血清状况的了解是获得 HIV 服务和及时进行抗逆转录病毒治疗的障碍,这可能会导致 HIV 传播和与 HIV 相关的疾病(包括结核病)的发生。

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