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埃塞俄比亚圣彼得结核病专科医院接受高效抗逆转录病毒治疗的艾滋病毒患者中的结核病合并感染及相关因素:一项五年回顾性研究

TB co-infection and associated factors among HIV patients attending highly active antiretroviral therapy in Saint Peter's TB Specialized Hospital, Ethiopia: a five years retrospective study.

作者信息

Getaw Dereje, Tigu Fitsum

机构信息

Department of Biology, Addis Ababa University, Addis Ababa, Ethiopia.

Department of Microbial, Cellular and Molecular Biology, Addis Ababa University, Addis Ababa, Ethiopia.

出版信息

Afr Health Sci. 2024 Jun;24(2):54-61. doi: 10.4314/ahs.v24i2.7.

Abstract

BACKGROUND

TB and HIV are the two widely distributed and successful microbial diseases which impose public health problems globally.

OBJECTIVES

The study aimed to determine the prevalence and associated factors of TB among people living with HIV (PLHIV).

METHODS

A retrospective study was conducted among PLHIV at Saint Peter's TB Specialized Hospital (SPTSH). Study participants were selected by random sampling technique. Logistic regression analyses were employed to determine the associations between dependent and independent variables. P ≤ 0.05 was taken as statistically significant.

RESULTS

The prevalence of TB among PLHIV in the entire study population was 24.6%. The proportion of pulmonary TB (PTB), disseminated TB (DTB) and extra pulmonary TB (EPTB), were 49 (57.6%), 9 (10.6%) and 27 (31.8%), respectively. Logistic regression analysis showed that PLHIV who are non-adhered to ART (AOR = 51.6, 95% CI 24.18 - 387), HAART duration of > 35 months (AOR = 0.39, 95% CI 0.198 - 2.10) and WHO clinical stage IV (AOR = 40.14, 95% CI15.14 - 106.44), were significantly associated with TB/HIV co-infection.

CONCLUSIONS

TB co-infection is the major public health issue of PLHIV. Special emphasis is required to reduce the incidence of TB/HIV associated morbidity and mortality among PLHIV.

摘要

背景

结核病和艾滋病是两种广泛传播且影响严重的微生物疾病,在全球范围内引发公共卫生问题。

目的

本研究旨在确定艾滋病毒感染者(PLHIV)中结核病的患病率及相关因素。

方法

在圣彼得结核病专科医院(SPTSH)对艾滋病毒感染者进行了一项回顾性研究。研究参与者采用随机抽样技术选取。采用逻辑回归分析来确定因变量和自变量之间的关联。P≤0.05被视为具有统计学意义。

结果

在整个研究人群中,艾滋病毒感染者中结核病的患病率为24.6%。肺结核(PTB)、播散性结核病(DTB)和肺外结核病(EPTB)的比例分别为49例(57.6%)、9例(10.6%)和27例(31.8%)。逻辑回归分析表明,未坚持接受抗逆转录病毒治疗的艾滋病毒感染者(调整后比值比[AOR]=51.6,95%置信区间[CI]为24.18 - 387)、高效抗逆转录病毒治疗(HAART)持续时间>35个月(AOR = 0.39,95% CI 0.198 - 2.10)以及世界卫生组织临床分期为IV期(AOR = 40.14,95% CI 15.14 - 106.44),均与结核病/艾滋病病毒合并感染显著相关。

结论

结核病合并感染是艾滋病毒感染者的主要公共卫生问题。需要特别强调降低艾滋病毒感染者中结核病/艾滋病病毒相关发病和死亡的发生率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c238/12341189/a74ec94895f8/AFHS2402-0054Fig1.jpg

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