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通过强化抗逆转录病毒疗法的可及性来扭转艾滋病毒流行趋势的进展:2012年肯尼亚一项具有全国代表性的基于人群的调查结果

Progress in Reversing the HIV Epidemic through Intensified Access to Antiretroviral Therapy: Results from a Nationally Representative Population-Based Survey in Kenya, 2012.

作者信息

Kim Andrea A, Mukui Irene, N'gan'ga Lucy, Katana Abraham, Koros Dan, Wamicwe Joyce, De Cock Kevin M

机构信息

US Centers for Disease Control and Prevention, Division of Global HIV and Tuberculosis, Nairobi, Kenya.

Ministry of Health, National AIDS and STI Control Programme, Nairobi, Kenya.

出版信息

PLoS One. 2016 Mar 1;11(3):e0148068. doi: 10.1371/journal.pone.0148068. eCollection 2016.

Abstract

BACKGROUND

In 2014, the Joint United Nations Programme on HIV/AIDS (UNAIDS) called for 90% of persons living with HIV (PLHIV) to know their status, 90% of these to be on antiretroviral therapy (ART), and 90% of these to be virally suppressed by 2020 (90-90-90). It is not clear whether planned ART scale-up in countries whose eligibility criteria for ART initiation are based on recommendations from the 2013 World Health Organization treatment guidelines will be sufficient to meet UNAIDS' new global targets.

MATERIALS AND METHODS

Using data from a nationally representative population-based household survey of persons in Kenya we compared coverage and unmet need associated with HIV diagnosis, ART, and viral suppression among PLHIV aged 15-64 years in 2012 based on criteria outlined in the 2014 national ART guidelines and UNAIDS' 90-90-90 goals. Estimates were weighted to account for sampling probability and nonresponse.

RESULTS

Eight in ten PLHIV aged 15-64 years needed ART based on treatment eligibility. Need for treatment based on the national treatment policy was 97.4% of treatment need based on UNAIDS' 90-90-90 goals, requiring an excess of 24,000 PLHIV to access treatment beyond those eligible for ART to achieve UNAIDS' 90-90-90 treatment target. The gap in treatment coverage was high, ranging from 43.1% nationally to 52.3% in Nyanza among treatment-eligible PLHIV and 44.6% nationally to 52.4% in Nyanza among all PLHIV.

CONCLUSION

Maintaining the current pace of ART scale-up in Kenya will result in thousands of PLHIV unreached, many with high viral load and at-risk of transmitting infection to others. Careful strategies for reaching 90-90-90 will be instrumental in determining whether intensified access to treatment can be achieved to reach all who require ART.

摘要

背景

2014年,联合国艾滋病规划署(UNAIDS)呼吁到2020年,90%的艾滋病毒感染者(PLHIV)知晓自身感染状况,其中90%接受抗逆转录病毒治疗(ART),且这些接受治疗者中有90%实现病毒抑制(90-90-90目标)。目前尚不清楚,对于那些依据2013年世界卫生组织治疗指南的建议来确定ART治疗起始资格标准的国家,按计划扩大ART治疗规模是否足以实现UNAIDS的新全球目标。

材料与方法

利用肯尼亚一项具有全国代表性的基于人群的家庭调查数据,我们根据2014年国家ART治疗指南及UNAIDS的90-90-90目标中概述的标准,比较了2012年15至64岁PLHIV中与艾滋病毒诊断、ART治疗及病毒抑制相关的覆盖率和未满足的需求。估计值经过加权以考虑抽样概率和无应答情况。

结果

依据治疗资格,每十名15至64岁的PLHIV中有八名需要接受ART治疗。基于国家治疗政策的治疗需求占基于UNAIDS的90-90-90目标的治疗需求的97.4%,要实现UNAIDS的90-90-90治疗目标,除了符合ART治疗资格者外,还需要超过24000名PLHIV获得治疗。治疗覆盖率差距很大,在符合治疗条件的PLHIV中,全国范围为43.1%,在尼扬扎为52.3%;在所有PLHIV中,全国范围为44.6%,在尼扬扎为52.4%。

结论

在肯尼亚维持当前扩大ART治疗规模的速度将导致数千名PLHIV无法得到治疗,其中许多人的病毒载量很高,且有将感染传播给他人的风险。实现90-90-90目标的审慎策略对于确定能否强化治疗可及性以惠及所有需要ART治疗者将起到重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a22e/4773218/ceb363c84c94/pone.0148068.g001.jpg

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