Ovol 蛋白：上皮细胞分化过程中 EMT 的守护者。
Ovol proteins: guardians against EMT during epithelial differentiation.
机构信息
Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.
Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
出版信息
Dev Cell. 2014 Apr 14;29(1):1-2. doi: 10.1016/j.devcel.2014.04.002.
Abstract
Epithelial differentiation requires a balancing act to commit to epithelial fate while inhibiting both progenitor and mesenchymal traits. In this issue of Developmental Cell, Lee et al. (2014) and Watanabe et al. (2014) uncover a critical role of Ovol proteins in safeguarding this intricate process.
摘要
上皮细胞分化需要在.commit 上皮命运的同时抑制祖细胞和间充质特征之间保持平衡。在本期《发育细胞》中，Lee 等人（2014 年）和 Watanabe 等人（2014 年）揭示了 Ovol 蛋白在保障这一复杂过程中的关键作用。
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本文引用的文献
1
Mammary morphogenesis and regeneration require the inhibition of EMT at terminal end buds by Ovol2 transcriptional repressor.乳腺形态发生和再生需要 Ovol2 转录抑制因子抑制末端芽的 EMT。
Dev Cell. 2014 Apr 14;29(1):59-74. doi: 10.1016/j.devcel.2014.03.006.
2
Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells.转录机制将上皮细胞可塑性与表皮祖细胞的黏附和分化联系起来。
Dev Cell. 2014 Apr 14;29(1):47-58. doi: 10.1016/j.devcel.2014.03.005.
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