Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.
Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
Dev Cell. 2014 Apr 14;29(1):1-2. doi: 10.1016/j.devcel.2014.04.002.
Epithelial differentiation requires a balancing act to commit to epithelial fate while inhibiting both progenitor and mesenchymal traits. In this issue of Developmental Cell, Lee et al. (2014) and Watanabe et al. (2014) uncover a critical role of Ovol proteins in safeguarding this intricate process.
上皮细胞分化需要在.commit 上皮命运的同时抑制祖细胞和间充质特征之间保持平衡。在本期《发育细胞》中，Lee 等人（2014 年）和 Watanabe 等人（2014 年）揭示了 Ovol 蛋白在保障这一复杂过程中的关键作用。
