DEP 结构域：结构相似而功能不同。
DEP domains: structurally similar but functionally different.
机构信息
Molecular Cancer Research and Cancer Genomics Netherlands, Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, Utrecht, The Netherlands.
Department of Cell Biology, Center for Molecular Medicine, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
出版信息
Nat Rev Mol Cell Biol. 2014 May;15(5):357-62. doi: 10.1038/nrm3791. Epub 2014 Apr 16.
The Dishevelled, EGL-10 and pleckstrin (DEP) domain is a globular protein domain that is present in about ten human protein families with well-defined structural features. A picture is emerging that DEP domains mainly function in the spatial and temporal control of diverse signal transduction events by recruiting proteins to the plasma membrane. DEP domains can interact with various partners at the membrane, including phospholipids and membrane receptors, and their binding is subject to regulation.
Dishevelled、EGL-10 和 pleckstrin (DEP) 结构域是一种球形蛋白结构域，存在于大约十个具有明确结构特征的人类蛋白家族中。目前出现的情况是，DEP 结构域主要通过将蛋白质募集到质膜上来发挥作用，从而在时空上控制各种信号转导事件。DEP 结构域可以与膜上的各种伙伴相互作用，包括磷脂和膜受体，并且它们的结合受到调节。
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