C3型葡萄球菌肠毒素基因的核苷酸序列表明，基因间重组导致抗原变异。
Nucleotide sequence of the type C3 staphylococcal enterotoxin gene suggests that intergenic recombination causes antigenic variation.
作者信息
Couch J L, Betley M J
机构信息
Department of Bacteriology, University of Wisconsin-Madison 53706.
出版信息
J Bacteriol. 1989 Aug;171(8):4507-10. doi: 10.1128/jb.171.8.4507-4510.1989.
Abstract
The nucleotide sequence of the structural gene for staphylococcal enterotoxin type C3 (entC3) was determined. This gene contains 798-base-pair open reading frame that encodes a protein of 266 amino acid residues. Sequence analysis suggests that staphylococcal enterotoxin type C3 is synthesized in a precursor form that is processed to yield a mature extracellular form of 238 amino acid residues (molecular weight, 27,438). The entC3 gene is closely related to the gene for staphylococcal enterotoxin type C1, with 98% nucleotide sequence identity. Sequence comparisons between the entC3, entC1, and entB genes suggest that an ancestral entC1-like gene was formed by recombination between the entC3 and entB genes.
摘要
测定了葡萄球菌C3型肠毒素（entC3）结构基因的核苷酸序列。该基因包含一个798个碱基对的开放阅读框，编码一个由266个氨基酸残基组成的蛋白质。序列分析表明，葡萄球菌C3型肠毒素以前体形式合成，经过加工后产生成熟的细胞外形式，由238个氨基酸残基组成（分子量为27,438）。entC3基因与葡萄球菌C1型肠毒素基因密切相关，核苷酸序列同一性为98%。entC3、entC1和entB基因之间的序列比较表明，一个祖先的entC1样基因是由entC3和entB基因之间的重组形成的。
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