Chakraborty Debrup, Wang Jing
Department of Cancer Biology and Genetics, James Comprehensive Cancer Center, The Ohio State University, BRT-860, 460 W 12th Ave, Columbus, OH 43210, United States of America.
Life Sci. 2020 Dec 1;262:118507. doi: 10.1016/j.lfs.2020.118507. Epub 2020 Oct 2.
Nonalcoholic fatty liver disease (NAFLD) is one of the major metabolic diseases that occur in almost one in every four global population, while colorectal cancer (CRC) is one of the leading causes of cancer related deaths in the world. Individuals with pre-existing NAFLD show a higher rate of developing CRC and liver metastasis, suggesting a causal relationship. Interestingly, both of these diseases are strongly associated with obesity, which is also a growing global health concern. In this current review, we will explore scientific findings that demonstrate the relationship between NAFLD, CRC and obesity, as well as the underlying mechanisms. We will also indicate the missing links and knowledge gaps that require more in-depth investigation.
非酒精性脂肪性肝病（NAFLD）是主要的代谢性疾病之一，全球近四分之一的人口受其影响，而结直肠癌（CRC）是全球癌症相关死亡的主要原因之一。已有NAFLD的个体患CRC和肝转移的几率更高，这表明二者之间存在因果关系。有趣的是，这两种疾病都与肥胖密切相关，而肥胖也是一个日益严重的全球健康问题。在本综述中，我们将探讨表明NAFLD、CRC与肥胖之间关系的科学发现及其潜在机制。我们还将指出需要更深入研究的缺失环节和知识空白。
