绿茶补充剂对超重和肥胖成年人血压的影响：一项系统评价方案
Effect of green tea supplementation on blood pressure among overweight and obese adults: a protocol for a systematic review.
作者信息
Li Guowei, Zhang Yuan, Mbuagbaw Lawrence, Holbrook Anne, Levine Mitchell A H, Thabane Lehana
机构信息
Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada.
出版信息
BMJ Open. 2014 Apr 17;4(4):e004971. doi: 10.1136/bmjopen-2014-004971.
INTRODUCTION
Emerging randomised controlled trials (RCTs) exploring the effect of green tea (GT) supplementation or GT extract (GTE) on blood pressure (BP) among overweight and obese adults yielded inconclusive results. We aim to conduct a systematic review to summarise the evidence of RCTs until now, to clarify the efficacy of GT supplementation or GTE in BP in overweight and obese populations.
METHODS AND ANALYSIS
The Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE and ClinicalTrials.gov will be searched to retrieve potential RCTs. Unpublished studies will be identified by searching the abstract books or websites of the three major conference proceedings: the International Society of Hypertension, the Nutrition & Health Conference and the World Congress of Nutrition and Health. A random-effects meta-analysis will be performed to pool the mean difference for the change in BP from baseline (ie, postintervention BP minus baseline BP) between intervention groups and placebo groups of the included studies, presenting the pooled results with 95% CIs. Subgroups analyses will be conducted according to different doses of GT or GTE, trial duration, geographic regions, overweight versus obese participants, and participants with versus without change in body weight after intervention. Sensitivity analysis will be performed by excluding studies classified as having a high risk of bias, applying a fixed-effects model, using the postintervention BP for analyses and excluding trials with non-study cointerventions.
ETHICS AND DISSEMINATION
This systematic review will be published in a peer-reviewed journal. It will be disseminated electronically and in print. Summarising the RCT evidence to clarify the efficacy in BP among overweight and obese adults will aid in making the dietary recommendation of GT and improving the clinical management of hypertension.
TRIAL REGISTRATION NUMBER
PROSPERO CRD42014007273.
引言
新兴的随机对照试验（RCT）探讨了补充绿茶（GT）或绿茶提取物（GTE）对超重和肥胖成年人血压（BP）的影响，结果尚无定论。我们旨在进行一项系统评价，总结迄今为止RCT的证据，以阐明补充GT或GTE对超重和肥胖人群血压的疗效。
方法与分析
将检索Cochrane对照试验中央注册库、MEDLINE、EMBASE和ClinicalTrials.gov，以检索潜在的RCT。通过检索三大会议论文集（国际高血压学会、营养与健康会议、世界营养与健康大会）的摘要书籍或网站来识别未发表的研究。将进行随机效应荟萃分析，汇总纳入研究中干预组和安慰剂组血压从基线变化的平均差异（即干预后血压减去基线血压），并给出95%置信区间的汇总结果。将根据GT或GTE的不同剂量、试验持续时间、地理区域、超重与肥胖参与者以及干预后体重有变化与无变化的参与者进行亚组分析。敏感性分析将通过排除被归类为具有高偏倚风险的研究、应用固定效应模型、使用干预后血压进行分析以及排除有非研究共同干预措施的试验来进行。
伦理与传播
本系统评价将发表在同行评审期刊上。将以电子和印刷形式传播。总结RCT证据以阐明超重和肥胖成年人血压的疗效，将有助于做出关于GT的饮食建议并改善高血压的临床管理。
试验注册号
PROSPERO CRD42014007273。
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