补充绿茶对超重和肥胖成年人血压的影响：一项系统评价和荟萃分析。
Effect of green tea supplementation on blood pressure among overweight and obese adults: a systematic review and meta-analysis.
作者信息
Li Guowei, Zhang Yuan, Thabane Lehana, Mbuagbaw Lawrence, Liu Aiping, Levine Mitchell A H, Holbrook Anne
机构信息
aDepartment of Clinical Epidemiology and Biostatistics bSt Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada cDepartment of Social Medicine and Health Education, Health Science Center, Peking University, Beijing, China.
出版信息
J Hypertens. 2015 Feb;33(2):243-54. doi: 10.1097/HJH.0000000000000426.
BACKGROUND
Emerging randomized controlled trials (RCTs) investigating the effect of green tea or green tea extract (GTE) supplementation on blood pressure (BP) among overweight and obese adults reported inconsistent findings.
OBJECTIVE
To conduct a systematic review and meta-analysis to clarify the efficacy of green tea or GTE on BP among overweight and obese adults.
METHODS
Electronic databases, conference proceedings and gray literature were searched systematically to include parallel and cross-over RCTs examining the efficacy of green tea or GTE on BP compared with placebo. Data were meta-analyzed using a random-effects model, to compare the mean difference of the change in BP from baseline in the intervention and the placebo groups.
RESULTS
Fourteen RCTs with 971 participants (47% women) were pooled for analysis. Green tea or GTE produced a significant effect on both SBP (mean difference -1.42 mmHg, 95% confidence interval -2.47 to -0.36, P = 0.008; I = 52%, P = 0.01 for heterogeneity) and DBP (mean difference -1.25 mmHg, 95% confidence interval -2.32 to -0.19, P = 0.02; I = 74%, P < 0.001 for heterogeneity), compared with placebo. The quality of evidence across studies was low. Similar results were found in subgroup and sensitivity analyses.
CONCLUSION
Among overweight and obese adults, green tea or GTE supplementation is found to cause a small but significant reduction in BP. More high-quality RCTs with large sample sizes are needed to further confirm the efficacy on BP and make strong recommendations for green tea or GTE supplementation among the overweight and obese adults.
背景
新兴的随机对照试验（RCT）研究了超重和肥胖成年人补充绿茶或绿茶提取物（GTE）对血压（BP）的影响，报告结果不一致。
目的
进行系统评价和荟萃分析，以阐明绿茶或GTE对超重和肥胖成年人血压的疗效。
方法
系统检索电子数据库、会议论文集和灰色文献，纳入比较绿茶或GTE与安慰剂对血压疗效的平行和交叉RCT。采用随机效应模型对数据进行荟萃分析，比较干预组和安慰剂组血压从基线变化的平均差异。
结果
纳入14项RCT，共971名参与者（47%为女性）进行分析。与安慰剂相比，绿茶或GTE对收缩压（平均差异-1.42 mmHg，95%置信区间-2.47至-0.36，P = 0.008；I² = 52%，异质性P = 0.01）和舒张压（平均差异-1.25 mmHg，95%置信区间-2.32至-0.19，P = 0.02；I² = 74%，异质性P < 0.001）均有显著影响。各研究的证据质量较低。亚组分析和敏感性分析结果相似。
结论
在超重和肥胖成年人中，补充绿茶或GTE可使血压有小幅但显著的降低。需要更多大样本量的高质量RCT来进一步证实其对血压的疗效，并就超重和肥胖成年人补充绿茶或GTE提出有力建议。
Zotero 插件