Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands.
Curr Opin Support Palliat Care. 2014 Jun;8(2):180-7. doi: 10.1097/SPC.0000000000000053.
Oral mucositis is one of the most prevalent toxicities after hematopoietic stem cell transplantation. Mucositis is initiated by the chemotherapy or radiotherapy preceding the transplantation. It is commonly accepted that microorganisms play a role in the process of oral mucositis. Despite the upcoming techniques to determine the whole oral bacterial ecosystem, the exact role of the microflora in mucositis is not yet understood. This article provides an overview of the state-of-the-art research on the oral microflora and mucositis.
A shift in microflora, in both the intestine and the oral cavity, can be found after chemotherapy or radiation therapy. The presence of oral ulcerative mucositis coincides with the presence of periodontitis-associated bacteria, in particular Porphyromonas gingivalis. Moreover, this bacterium can inhibit wound healing processes in an in-vitro model.
We come to realize that some diseases are associated with a shift in the microflora. The role of the microflora in oral and intestinal mucositis is gaining more attention in recent literature. In the oral cavity, periodontitis-associated bacteria may influence the healing of ulcerations and the role they play in mucositis may be more subtle and complicated than was previously thought.
异基因造血干细胞移植后，口腔黏膜炎是最常见的毒性反应之一。黏膜炎由移植前的化疗或放疗引起。目前普遍认为微生物在口腔黏膜炎的发生发展中起作用。尽管即将采用新技术来确定整个口腔细菌生态系统，但微生物菌群在黏膜炎中的确切作用尚不清楚。本文概述了口腔微生物菌群与黏膜炎的最新研究进展。
化疗或放疗后，肠道和口腔的微生物菌群都会发生变化。在存在溃疡性口腔黏膜炎的同时，还存在牙周病相关细菌，特别是牙龈卟啉单胞菌。此外，该细菌可以在体外模型中抑制伤口愈合过程。
我们逐渐认识到某些疾病与微生物菌群的变化有关。微生物菌群在口腔和肠道黏膜炎中的作用在最近的文献中受到越来越多的关注。在口腔中，牙周病相关细菌可能影响溃疡的愈合，它们在黏膜炎中的作用可能比以前认为的更微妙和复杂。
