Scandling J, Walker B K
South Med J. 1980 Nov;73(11):1470-2. doi: 10.1097/00007611-198011000-00015.
Skin and soft tissue necrosis is an uncommon but increasingly recognized complication of coumarin anticoagulant therapy. A patient is described with extensive involvement of all four extremities and the nose, requiring amputation of three extremities. The characteristic clinical features of the disorder are reviewed, with a discussion of the pathology, pathogenesis, and possible treatment modalities.
皮肤和软组织坏死是香豆素抗凝治疗一种罕见但日益被认识到的并发症。本文描述了一名患者，其四肢及鼻部均广泛受累，需对三个肢体进行截肢。文中回顾了该疾病的特征性临床特点，并讨论了其病理、发病机制及可能的治疗方式。
