Diskapi Children's Hospital, Department of Pediatric Hematology, Ankara, Turkey.
Ulucanlar Eye Hospital, Ankara, Turkey.
Turk J Haematol. 2012 Jun;29(2):181-4. doi: 10.5505/tjh.2012.72623. Epub 2012 Jun 15.
Ocular findings are rarely the initial symptom of leukemia, although up to 90% of all leukemia patients have fundus changes during the course of the disease. Herein we report a relapsing acute lymphoblastic leukemia patient with thesole presentation of sudden visual loss and exudative retinal detachment. An 8-year-old boy with acute lymphoblasticleukemia developed sudden visual loss during his first remission period. Bullous retinal detachment with total afferentpupillary defect was observed. Orbital magnetic resonance imaging revealed an intraocular mass lesion; simultaneouslyobtained bone marrow and cerebrospinal fluid samples showed no evidence of leukemic cells. Following local irradiation,and systemic and intrathecal chemotherapy the mass disappeared. Local irradiation, and systemic and intrathecalchemotherapy effectively controlled the isolated ocular relapse of acute lymphoblastic leukemia and eliminated the needfor enucleation.
眼部表现很少是白血病的首发症状，尽管在疾病过程中高达 90%的所有白血病患者都有眼底改变。在此，我们报告一例以突发性视力丧失和渗出性视网膜脱离为唯一表现的复发性急性淋巴细胞白血病患者。一名 8 岁男孩患有急性淋巴细胞白血病，在首次缓解期出现突发性视力丧失。观察到伴有完全性传入性瞳孔障碍的大疱性视网膜脱离。眼眶磁共振成像显示眼内肿块病变；同时获得的骨髓和脑脊液样本均未显示白血病细胞。局部放疗，全身和鞘内化疗后肿块消失。局部放疗，全身和鞘内化疗有效控制了急性淋巴细胞白血病的孤立性眼部复发，避免了眼球摘除的需要。
