Azarcon Corrina P, Mercado Gary John V, Alfonso Rachelle N
Department of Ophthalmology and Visual Sciences, Philippine General Hospital, University of the Philippines - Manila, Manila, Philippines.
College of Medicine, University of the Philippines - Manila, Manila, Philippines.
Neuroophthalmology. 2021 Jun 11;46(2):126-130. doi: 10.1080/01658107.2021.1933079. eCollection 2022.
Isolated ocular relapse of leukaemia is rare. We present the case of a 20-year-old male with T-cell acute lymphoblastic leukaemia (ALL) who reported sudden blurring of vision in both eyes 6 months after documentation of ALL remission. Ocular examination showed bilateral infiltrative optic neuropathies and serous retinal detachments. Cerebrospinal fluid and bone marrow samples were negative for blast cells. Systemic work-up did not reveal any other sites of involvement. The ocular infiltration partially responded to reinduction chemotherapy, intraconal steroids, and radiotherapy. This report demonstrates a challenging case of isolated ocular ALL relapse presenting as bilateral optic nerve and retinal infiltration.
白血病孤立性眼部复发罕见。我们报告一例20岁男性T细胞急性淋巴细胞白血病（ALL）患者，其在ALL缓解记录6个月后出现双眼突发视力模糊。眼部检查显示双侧浸润性视神经病变和浆液性视网膜脱离。脑脊液和骨髓样本中未发现原始细胞。全身检查未发现其他受累部位。眼部浸润对再诱导化疗、球后注射类固醇和放疗有部分反应。本报告展示了一例具有挑战性的孤立性眼部ALL复发病例，表现为双侧视神经和视网膜浸润。
