Faller Kiterie, Penderis Jacques, Stalin Catherine, Guevar Julien, Yeamans Carmen, Gutierrez-Quintana Rodrigo
School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden Road, Glasgow, G61 1QH, UK.
School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden Road, Glasgow, G61 1QH, UK.
Vet J. 2014 Jun;200(3):449-51. doi: 10.1016/j.tvjl.2014.03.027. Epub 2014 Mar 31.
In people, abnormalities in vertebral column conformation, such as kyphoscoliosis, induce degenerative changes in adjacent intervertebral disc (IVD) structure and composition. It was hypothesised that canine IVDs adjacent to a vertebral malformation undergo early degeneration. In a blinded retrospective study, thoracic IVD degeneration was evaluated in 14 dogs on magnetic resonance images using Pfirrmann's grade. IVDs adjacent to a vertebral malformation had higher grades of degeneration than non-adjacent IVDs (P < 0.0001). There was an age-dependency, with dogs between 1 and 4 years showing higher grade of degeneration in adjacent than non-adjacent IVDs (P < 0.0001). Conversely, in older dogs, all IVDs - including the non-adjacents - showed degenerative signs, possibly due to normal aging. These results suggest that congenital vertebral malformation results in early degeneration of adjacent IVDs.
在人类中，脊柱形态异常，如脊柱后凸侧弯，会导致相邻椎间盘（IVD）的结构和组成发生退行性变化。据推测，与脊柱畸形相邻的犬类IVD会过早退化。在一项盲法回顾性研究中，使用Pfirrmann分级在磁共振图像上评估了14只犬的胸段IVD退变情况。与脊柱畸形相邻的IVD比不相邻的IVD有更高的退变分级（P < 0.0001）。存在年龄依赖性，1至4岁的犬中，相邻IVD的退变分级高于不相邻的IVD（P < 0.0001）。相反，在老年犬中，所有IVD（包括不相邻的）都显示出退变迹象，这可能是由于正常衰老所致。这些结果表明，先天性脊柱畸形会导致相邻IVD过早退化。
