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沙枣花中的酰化黄酮醇苷

Acylated flavonol glycosides from the flower of Elaeagnus angustifolia L.

作者信息

Bendaikha Sarah, Gadaut Méredith, Harakat Dominique, Magid Alabdul

机构信息

Groupe Isolement et Structure, Institut de Chimie Moléculaire de Reims (ICMR), CNRS UMR 7312, UFR de Pharmacie, BP 1039, 51687 Reims, France.

Service Commun d'Analyses, Institut de Chimie Moléculaire de Reims (ICMR), CNRS UMR 7312, Bat. 18, BP 1039, 51687 Reims Cedex 2, France.

出版信息

Phytochemistry. 2014 Jul;103:129-136. doi: 10.1016/j.phytochem.2014.03.025. Epub 2014 Apr 15.

Abstract

Seven acylated flavonol glycosides named elaeagnosides A-G, in addition to seven known flavonoids were isolated from the flowers of Elaeagnus angustifolia. Their structures were elucidated by different spectroscopic methods including 1D, 2D NMR experiments and HR-ESI-MS analysis. In order to identify natural antioxidant and tyrosinase inhibitor agents, the abilities of these flavonoids to scavenge the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and to inhibit tyrosinase activity were evaluated. Results revealed that two of these compounds had significant anti-oxidant effect and one compound showed weak tyrosinase-inhibitory activity compared with kojic acid, quercetin, or ascorbic acid, which were used as positive control.

摘要

从沙枣花中分离出七种酰化黄酮醇苷,命名为沙枣苷A - G,此外还分离出七种已知黄酮类化合物。通过包括一维、二维核磁共振实验和高分辨电喷雾电离质谱分析在内的不同光谱方法阐明了它们的结构。为了鉴定天然抗氧化剂和酪氨酸酶抑制剂,评估了这些黄酮类化合物清除1,1 - 二苯基 - 2 - 苦基肼自由基(DPPH)的能力以及抑制酪氨酸酶活性的能力。结果表明,与用作阳性对照的曲酸、槲皮素或抗坏血酸相比,其中两种化合物具有显著的抗氧化作用,一种化合物表现出较弱的酪氨酸酶抑制活性。

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