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[维吾尔族传统草药沙枣花的化学成分]

[Chemical constituents from traditional Uighur herbal medicine Elaeagnus angustifolia flowers].

作者信息

Chen Xiao-Yu, Han Jian-Xin, Liu Yu-Shuang, Hajiakber Aisa, Yuan Tao

机构信息

The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Chinese Academy of Sciences, State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China.

University of Chinese Academy of Sciences, Beijing 100049, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2018 May;43(9):1749-1753. doi: 10.19540/j.cnki.cjcmm.20180115.020.

Abstract

Seven aromatic glycosides (1-7), including four phenylethanol glycosides, one phenylmethanol glycoside, one phenylpropane glycoside and one benzoside, were isolated from the methanolic extract of Uighur Medicine Elaeagnus angustifolia flowers. Their structures were elucidated based on the analysis of spectroscopic data (1D, 2D NMR and HR-MS). Compound 1 is a new compound, named as angustifol A. Six known compounds were identified as 2-phenylethyl-O-β-D-glucopyranoside(2), salidroside (3), vanillic acid 4-O-β-D-glucopyranoside(4), vanilloloside (5), (Z)-isoconiferin (6), 2-phenylethyl-6-O-α-L-arabinofuranosyl-β-D-glucopyranoside (7). Compounds 2-7 were isolated from the genus Elaeagnus for the first time. In vitro anti-inflammatory assays revealed that none of these compounds showed good COX inhibitory activities.

摘要

从维吾尔药沙枣花的甲醇提取物中分离出七种芳香糖苷(1-7),包括四种苯乙醇苷、一种苯甲醇苷、一种苯丙烷苷和一种苯甲苷。通过光谱数据(一维、二维核磁共振和高分辨质谱)分析确定了它们的结构。化合物1是一种新化合物,命名为沙枣苷A。六种已知化合物分别鉴定为2-苯乙基-O-β-D-吡喃葡萄糖苷(2)、红景天苷(3)、香草酸4-O-β-D-吡喃葡萄糖苷(4)、香草醇苷(5)、(Z)-异松柏苷(6)、2-苯乙基-6-O-α-L-阿拉伯呋喃糖基-β-D-吡喃葡萄糖苷(7)。化合物2-7首次从沙枣属植物中分离得到。体外抗炎试验表明,这些化合物均未表现出良好的环氧化酶抑制活性。

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