传统药材胡颓子花中的三萜皂苷和木脂素糖苷及其细胞毒性活性。
Triterpenoid Saponin and Lignan Glycosides from the Traditional Medicine Elaeagnus angustifolia Flowers and Their Cytotoxic Activities.
机构信息
Department of Food Science and Nutrition, School of Biosystems Engineering and Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou 310058, China.
The Key Laboratory of Plant Resources and Chemistry of Arid Zone, and State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China.
出版信息
Molecules. 2020 Jan 22;25(3):462. doi: 10.3390/molecules25030462.
A new triterpenoid saponin, named terpengustifol A (), and two new lignan glucosides, phengustifols A and B ( and ), were isolated from the flowers of . Their structures were determined by the extensive analysis of the spectroscopic data (including NMR and HRMS) and ECD calculations. Compound possesses an unusual monoterpene ()-6-hydroxy-2,6-dimethylocta-2,7-dienoyl unit at C-21. Compounds and are a pair of diastereoisomers, while their aglycones are a pair of enantiomers. Compounds and exhibited moderate cytotoxic activities against A375 cell lines with IC values at 12.1 and 15.6 μM, respectively. This is firstly reported the triterpenoid saponin and lignans isolated from the flowers.
从瓜馥木的花中分离得到了 3 个新的三萜皂苷，分别命名为 terpengustifol A (1)、phengustifols A (2) 和 B (3)，以及 2 个新的木脂素葡萄糖苷。通过对光谱数据（包括 NMR 和 HRMS）和 ECD 计算的广泛分析，确定了它们的结构。化合物 1 含有一个在 C-21 上的罕见的单萜 ()-6-羟基-2,6-二甲基辛-2,7-二烯酰基单元。化合物 2 和 3 是一对非对映异构体，而它们的苷元是一对对映异构体。化合物 1 和 3 对 A375 细胞系表现出中等的细胞毒性，IC 值分别为 12.1 和 15.6 μM。这是首次从瓜馥木的花中分离得到三萜皂苷和木脂素。
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