Chauhan Preeti S, Dash D, Singh Rashmi
Department of Zoology, MMV, Banaras Hindu University, Varanasi 221005, India.
Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
Int Immunopharmacol. 2014 Jul;21(1):63-75. doi: 10.1016/j.intimp.2014.03.021. Epub 2014 Apr 18.
Curcumin, phytochemical present in turmeric, rhizome of Curcuma longa, a known anti-inflammatory molecule with variety of pharmacological activities is found effective in murine model of chronic asthma characterized by structural alterations and airway remodeling. Here, we have investigated the effects of intranasal curcumin in chronic asthma where animals were exposed to allergen for longer time. In the present study Balb/c mice were sensitized by an intraperitoneal injection of ovalbumin (OVA) and subsequently challenged with 2% OVA in aerosol twice a week for five consecutive weeks. Intranasal curcumin (5mg/kg) was administered from days 21 to 55, an hour before every nebulization and inflammatory cells recruitment, levels of IgE, EPO, IL-4 and IL-5 were found suppressed in bronchoalveolar lavage fluid (BALF). Intranasal curcumin administration prevented accumulation of inflammatory cells to the airways, structural alterations and remodeling associated with chronic asthma like peribronchial and airway smooth muscle thickening, sloughing off of the epithelial lining and mucus secretion in ovalbumin induced murine model of chronic asthma.
姜黄素是姜黄（姜黄属植物姜黄的根茎）中存在的一种植物化学物质，是一种已知的具有多种药理活性的抗炎分子，在以结构改变和气道重塑为特征的慢性哮喘小鼠模型中被发现有效。在此，我们研究了鼻内给予姜黄素对慢性哮喘的影响，在该模型中动物长时间暴露于过敏原。在本研究中，通过腹腔注射卵清蛋白（OVA）使Balb/c小鼠致敏，随后连续五周每周两次用2% OVA气雾剂进行激发。从第21天至第55天，在每次雾化前一小时鼻内给予姜黄素（5mg/kg），发现支气管肺泡灌洗液（BALF）中的炎症细胞募集、IgE、EPO、IL-4和IL-5水平受到抑制。在卵清蛋白诱导的慢性哮喘小鼠模型中，鼻内给予姜黄素可防止炎症细胞在气道积聚、与慢性哮喘相关的结构改变和重塑，如支气管周围和气道平滑肌增厚、上皮衬里脱落和黏液分泌。
