Chen Jinju
School of Mechanical and Systems Engineering , Newcastle University , Newcastle Upon Tyne NE1 7RU , UK ; Arthritis Research UK (ARUK) Tissue Engineering Centre , Institute of Cellular Medicine, Newcastle University , Newcastle Upon Tyne NE2 4HH , UK.
Interface Focus. 2014 Apr 6;4(2):20130055. doi: 10.1098/rsfs.2013.0055.
Nanobiomechanics of living cells is very important to understand cell-materials interactions. This would potentially help to optimize the surface design of the implanted materials and scaffold materials for tissue engineering. The nanoindentation techniques enable quantifying nanobiomechanics of living cells, with flexibility of using indenters of different geometries. However, the data interpretation for nanoindentation of living cells is often difficult. Despite abundant experimental data reported on nanobiomechanics of living cells, there is a lack of comprehensive discussion on testing with different tip geometries, and the associated mechanical models that enable extracting the mechanical properties of living cells. Therefore, this paper discusses the strategy of selecting the right type of indenter tips and the corresponding mechanical models at given test conditions.
活细胞的纳米生物力学对于理解细胞与材料的相互作用非常重要。这可能有助于优化用于组织工程的植入材料和支架材料的表面设计。纳米压痕技术能够量化活细胞的纳米生物力学，并且可以灵活使用不同几何形状的压头。然而，对活细胞进行纳米压痕的数据解释往往很困难。尽管已经报道了大量关于活细胞纳米生物力学的实验数据，但对于使用不同尖端几何形状进行测试以及能够提取活细胞力学性能的相关力学模型，缺乏全面的讨论。因此，本文讨论了在给定测试条件下选择合适类型压头尖端和相应力学模型的策略。
