Woody R C, Steele R W, Charlton R K, Smith V
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock.
J Child Neurol. 1989 Jul;4(3):204-7. doi: 10.1177/088307388900400311.
Postinfectious encephalomyelitis and multiple sclerosis have clinical, immunologic, and neuroradiographic similarities. We studied HLA determinants in six white children consecutively diagnosed with postinfectious encephalomyelitis. Each of the children had HLA determinants which have been associated with multiple sclerosis. Relative risk (RR) calculations demonstrated that these antigens and genotypes occurred significantly more often in patients with postinfectious encephalomyelitis than in the control population (A3, RR 6.14; B7, RR 6.14; DR2, RR 4.51; A3B7, RR 9.36; A3DR2, RR 5.83; B7DR2, RR 6.13; A3B7DR2, RR 10.90). These data suggest that children with postinfectious encephalomyelitis are genetically predisposed to this demyelinating disease. Although the same HLA determinants were found in these patients as in those with multiple sclerosis, studies of a larger number of postinfectious encephalomyelitis patients will be needed before it can be concluded that the two diseases share a common genetic propensity.
感染后脑脊髓炎与多发性硬化症在临床、免疫及神经影像学方面存在相似之处。我们对连续6例被诊断为感染后脑脊髓炎的白人儿童进行了HLA决定簇研究。每个儿童都具有与多发性硬化症相关的HLA决定簇。相对危险度（RR）计算表明，这些抗原和基因型在感染后脑脊髓炎患者中出现的频率显著高于对照组人群（A3，RR 6.14；B7，RR 6.14；DR2，RR 4.51；A3B7，RR 9.36；A3DR2，RR 5.83；B7DR2，RR 6.13；A3B7DR2，RR 10.90）。这些数据表明，感染后脑脊髓炎患儿在遗传上易患这种脱髓鞘疾病。尽管在这些患者中发现了与多发性硬化症患者相同的HLA决定簇，但在得出这两种疾病具有共同遗传倾向的结论之前，还需要对更多感染后脑脊髓炎患者进行研究。
