奥克尼群岛和设得兰群岛的多发性硬化症。III：组织相容性决定因素。
Multiple sclerosis in the Orkney and Shetland Islands. III: Histocompatibility determinants.
作者信息
Poskanzer D C, Terasaki P I, Prenney L B, Sheridan J L, Park M S
出版信息
J Epidemiol Community Health. 1980 Dec;34(4):253-7. doi: 10.1136/jech.34.4.253.
Abstract
Histocompatibility testing was performed in 48 multiple sclerosis patients and two carefully matched control groups in Orkney Islands, an area of high multiple sclerosis prevalence. The frequency of HLA-A3, HLA-B7, and DW2 was comparable in patients and controls. However, HLA-B7 was significantly more common in female patients compared with male patients. A B-cell alloantigen (B-cell 4) was also as frequent in patients as among controls. Strong linkage between HLA-B7, DW2 and B-cell 4 occurred in controls, but not patients; the linkage was particularly striking in female controls. These data are not consistent with theories that relate certain of the histocompatibility antigens to the aetiology of multiple sclerosis.
摘要
在奥克尼群岛（多发性硬化症高发地区），对48例多发性硬化症患者和两个精心匹配的对照组进行了组织相容性检测。患者和对照组中HLA - A3、HLA - B7和DW2的频率相当。然而，与男性患者相比，HLA - B7在女性患者中明显更为常见。一种B细胞同种抗原（B细胞4）在患者中的出现频率与对照组相同。HLA - B7、DW2和B细胞4在对照组中存在强连锁关系，但在患者中不存在；这种连锁关系在女性对照组中尤为显著。这些数据与将某些组织相容性抗原与多发性硬化症病因联系起来的理论不一致。
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