混合型肝细胞癌-胆管细胞癌（cHCC-CC）：一种独特的实体。

Combined hepatocellular-cholangiocarcinoma (cHCC-CC): a distinct entity.

机构信息

Division of Anatomic Pathology, Vancouver General Hospital, Vancouver, British Columbia, Canada.

Department of Pathology, London Health Sciences Centre, London, Ontario, Canada; The University of Western Ontario (UWO), London, Ontario, Canada.

出版信息

Ann Hepatol. 2014 May-Jun;13(3):317-22.

PMID:24756005

Abstract

Patients with hepatocellular carcinoma (HCC), the fifth most common cancer worldwide, display a highly variable clinical course, suggesting that HCC encompasses several biologically distinct subtypes. This heterogeneity has the potential to impede both treatment decisions and prognostic predictions for patients with HCC. One distinct, albeit rare, subtype of HCC is combined hepatocellular-cholangiocarcinoma (cHCC-CC), which overall carries a poorer prognosis than HCC and cholangiocarcinoma (CC) alone. This review discusses predominantly the histopathologic and pathogenetic intricacies of this tumor and highlights the need for an accurate diagnosis of this specific HCC subtype.

摘要

肝细胞癌 (HCC) 是全球第五大常见癌症，患者的临床表现差异很大，这表明 HCC 包含几个生物学上不同的亚型。这种异质性有可能阻碍 HCC 患者的治疗决策和预后预测。HCC 的一个独特但罕见的亚型是肝细胞胆管细胞癌 (cHCC-CC)，其总体预后比 HCC 和单独的胆管细胞癌 (CC)更差。这篇综述主要讨论了这种肿瘤的组织病理学和发病机制的复杂性，并强调了准确诊断这种特定 HCC 亚型的必要性。