澳大利亚海绵 Aplysinella sp.中溴酪氨酸衍生代谢物 Aplysinellamides A-C

Aplysinellamides A-C, bromotyrosine-derived metabolites from an Australian Aplysinella sp. marine sponge.

机构信息

Eskitis Institute, Griffith University , Brisbane, QLD 4111, Australia.

出版信息

J Nat Prod. 2014 May 23;77(5):1210-4. doi: 10.1021/np500119e. Epub 2014 Apr 23.

Abstract

Mass-directed fractionation of an extract from the Australian marine sponge Aplysinella sp., from the Great Barrier Reef, resulted in the isolation of four new bromotyrosine derivatives, aplysinellamides A-C (1-3) and aplysamine-1-N-oxide (4), along with six known compounds (5-10). The structure elucidation of compounds 1-4 was based on their 1D and 2D NMR and MS spectroscopic data. Aplysamine-1 (6) increased the apolipoprotein E secretion from human CCF-STTG1 astrocytoma cells by 2-fold at the concentration of 30 μM.

摘要

从大堡礁澳大利亚海绵 Aplysinella sp. 的提取物中进行质量导向的分级分离，得到了四个新的溴酪氨酸衍生物，aplysinellamides A-C（1-3）和 aplysamine-1-N-oxide（4），以及六个已知化合物（5-10）。化合物 1-4 的结构阐明基于它们的 1D 和 2D NMR 和 MS 光谱数据。阿普林胺-1（6）在 30 μM 的浓度下使人类 CCF-STTG1 星形细胞瘤细胞中的载脂蛋白 E 分泌增加了 2 倍。