Niu Siwen, Liu Dong, Shao Zongze, Huang Jiang, Fan Aili, Lin Wenhan
State Key Laboratory of Natural and Biomimetic Drugs, Peking University Beijing 100191 P. R. China
Third Institute of Oceanography, SOA Xiamen 361005 P. R. China.
RSC Adv. 2021 Sep 3;11(47):29661-29667. doi: 10.1039/d1ra05736g. eCollection 2021 Sep 1.
Chromatographic separation of the solid cultures of a deep-sea-derived fungus (MCCC 3A00308) resulted in the isolation of eight compounds. Their structures were identified on the basis of the spectroscopic data. Compounds 1-8 are classified as depsidone-type (1-4), isocoumarin-type (5 and 6), and benzothiazole-type (7 and 8), of which 1-7 are new compounds and 1-3 along with 5 and 6 are chlorinated. Compound 3 is characterized by trichlorination and shows potent activities against Gram-positive pathogenic bacteria including ATCC 25923, ATCC 10792, and CMCC 63501, with minimum inhibitory concentration (MIC) values ranging from 0.5 to 1.0 μg mL. This study extends the chemical diversity of chlorinated natural products from marine-derived fungi and provides a promising lead for the development of antibacterial agents.
对一株深海来源真菌（MCCC 3A00308）的固体培养物进行色谱分离，得到了8种化合物。根据光谱数据确定了它们的结构。化合物1 - 8分为缩酚酸酮型（1 - 4）、异香豆素型（5和6）和苯并噻唑型（7和8），其中1 - 7为新化合物，1 - 3以及5和6含有氯元素。化合物3的特征是三氯化，对包括ATCC 25923、ATCC 10792和CMCC 63501在内的革兰氏阳性病原菌显示出强效活性，最低抑菌浓度（MIC）值范围为0.5至1.0 μg/mL。本研究扩展了海洋来源真菌中含氯天然产物的化学多样性，并为抗菌剂的开发提供了有前景的先导化合物。
