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人角质形成细胞生长因子与成纤维细胞生长因子相关，具有上皮细胞生长旁分泌效应因子的特性。

Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth.

作者信息

Finch P W, Rubin J S, Miki T, Ron D, Aaronson S A

机构信息

Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892.

出版信息

Science. 1989 Aug 18;245(4919):752-5. doi: 10.1126/science.2475908.

DOI:10.1126/science.2475908
PMID:2475908
Abstract

Keratinocyte growth factor (KGF) is a human mitogen that is specific for epithelial cells. The complementary DNA sequence of KGF demonstrates that it is a member of the fibroblast growth factor family. The KGF transcript was present in stromal cells derived from epithelial tissues. By comparison with the expression of other epithelial cell mitogens, only KGF, among known human growth factors, has the properties of a stromal mediator of epithelial cell proliferation.

摘要

角质形成细胞生长因子（KGF）是一种对上皮细胞具有特异性的人类促有丝分裂原。KGF的互补DNA序列表明它是成纤维细胞生长因子家族的一员。KGF转录本存在于源自上皮组织的基质细胞中。与其他上皮细胞促有丝分裂原的表达相比，在已知的人类生长因子中，只有KGF具有上皮细胞增殖的基质介质特性。

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