Xie Jing, Gabelle Audrey, Dorey Aline, Garnier-Crussard Antoine, Perret-Liaudet Armand, Delphin-Combe Floriane, Bathsavanis Anthony, Dauphinot Virginie, Lehmann Sylvain, Mercier Bernadette, Desestret Virginie, Roullet-Solignac Isabelle, Vighetto Alain, Krolak-Salmon Pierre
Research and Resources Memory Center of Lyon, Hôpital des Charpennes, Hospices Civils de Lyon, Lyon, France.
Research and Resources Memory Center of Montpellier, University Hospital of Montpellier, and INSERM U1040, Institute of Biotherapies, France.
J Alzheimers Dis. 2014;41(4):1109-16. doi: 10.3233/JAD-131916.
Alzheimer's disease (AD) clinical onset is usually characterized by a memory complaint and a progressive memory deficit. The proportion of typical medial-temporal amnesia revealing AD remains unknown.
The present study explores the episodic memory impairment profiles by the Free and Cued Selective Recall Reminding Test (FCSRT) in patients with initial memory complaint and a cerebrospinal fluid (CSF) biomarker signature of AD.
Seventy-three patients referred for memory complaint to the Centers for Memory, Resource and Research of Lyon and Montpellier (France) were included consecutively. All patients underwent an extensive neuropsychological examination and had a Mini-Mental State Examination (MMSE) score ≥20 and a positive CSF AD signature. The patients were classified as having mild dementia or prodromal AD. Verbal episodic memory was assessed using the French version of the FCSRT exploring encoding, storage/consolidation, and cued delayed retrieval phases of memorization. Three different memory profiles were identified according to the results of FCSRT.
The median age was 72 year-old [interquartiles: 65-76]. The median MMSE score was 23 [interquartiles: 21-25]. 88% of the patients (n = 64) presented with a medial temporal amnesia profile. The dysexecutive amnesia and normal verbal episodic memory profiles represented respectively 5% (n = 4) and 7% (n = 5). There were no significant differences in term of age, gender, and MMSE score between the three profile groups.
In a population initially presenting with memory complaints and depicting a CSF AD signature, a high proportion of medial temporal amnesia is disclosed as expected, but also a proportion of dysexecutive amnesia and normal FCSRT.
阿尔茨海默病（AD）的临床起病通常以记忆主诉和进行性记忆缺陷为特征。典型的内侧颞叶失忆症在AD中所占比例尚不清楚。
本研究通过自由和线索选择性回忆提醒测试（FCSRT），探索初始有记忆主诉且脑脊液（CSF）生物标志物呈AD特征的患者的情景记忆障碍模式。
连续纳入73名因记忆主诉转诊至法国里昂和蒙彼利埃记忆、资源与研究中心的患者。所有患者均接受了全面的神经心理学检查，简易精神状态检查表（MMSE）评分≥20，且脑脊液AD特征呈阳性。这些患者被分为轻度痴呆或前驱性AD。使用FCSRT的法语版本评估言语情景记忆，该测试探索记忆的编码、存储/巩固以及线索延迟检索阶段。根据FCSRT的结果确定了三种不同的记忆模式。
中位年龄为72岁[四分位间距：65 - 76岁]。MMSE评分中位数为23[四分位间距：21 - 25]。88%的患者（n = 64）呈现内侧颞叶失忆模式。执行功能障碍性失忆和正常言语情景记忆模式分别占5%（n = 4）和7%（n = 5）。三个模式组在年龄、性别和MMSE评分方面无显著差异。
在最初有记忆主诉且脑脊液呈AD特征的人群中，如预期的那样，发现高比例的内侧颞叶失忆症，但也有一定比例的执行功能障碍性失忆和FCSRT正常者。
