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神经精神科问卷量表在患有认知障碍的中风或短暂性脑缺血发作患者中的效度和信度

Validity and reliability of the neuropsychiatric inventory questionnaire version in patients with stroke or transient ischemic attack having cognitive impairment.

作者信息

Wong Adrian, Cheng Sheung-Tak, Lo Eugene S K, Kwan Pauline W L, Law Lorraine S N, Chan Anne Y Y, Wong Lawrence Ka-Sing, Mok Vincent

机构信息

Department of Psychological Studies, The Hong Kong Institute of Education, Tai-po, Hong Kong SAR, China Center for Psychosocial Health and Aging, The Hong Kong Institute of Education, Tai-po, Hong Kong SAR, China.

Department of Health and Physical Education, The Hong Kong Institute of Education, Tai-po, Hong Kong SAR, China.

出版信息

J Geriatr Psychiatry Neurol. 2014 Dec;27(4):247-52. doi: 10.1177/0891988714532017. Epub 2014 Apr 24.

DOI:10.1177/0891988714532017
PMID:24763069
Abstract

This study examined the validity and reliability of the Neuropsychiatric Inventory Questionnaire version (NPI-Q), a proxy-reported format of the interview-based NPI, in assessing neuropsychiatric symptoms in 173 patients with stroke or transient ischemic attack (TIA) having cognitive impairment. The NPI-Q was validated against the NPI as a gold standard. Informants took approximately 7 minutes to complete the NPI-Q. Bland-Altman analysis revealed a bias of 0.7 points, with 95% limits of agreement between -8.6 and 10.0 between the total symptom scores of the NPI and NPI-Q. The NPI-Q correlated significantly with the NPI in individual and total symptom scores and caregiver distress scores. In predicting presence of symptoms on the NPI, the NPI-Q yielded, on average, sensitivity of 74.1% and specificity of 79.5%. On the NPI-Q, informants tended to overreport symptoms in patients with less severe symptoms but underreport with increasing symptom severity. Internal consistency of the NPI-Q was acceptable (Cronbach's α = 0.756). One-week test-retest reliability of the NPI-Q was excellent (intraclass correlation coefficient = .990). The NPI-Q is a valid and reliable instrument for screening neuropsychiatric symptoms in patients with stroke and TIA.

摘要

本研究检验了神经精神科问卷量表（NPI-Q）这一基于访谈的NPI的代理报告形式，在评估173例患有认知障碍的中风或短暂性脑缺血发作（TIA）患者的神经精神症状方面的有效性和可靠性。以NPI作为金标准对NPI-Q进行验证。信息提供者完成NPI-Q大约需要7分钟。Bland-Altman分析显示偏差为0.7分，NPI和NPI-Q的总症状得分之间的95%一致性界限在-8.6至10.0之间。NPI-Q在个体症状得分、总症状得分及照料者痛苦得分方面与NPI显著相关。在预测NPI上症状的存在时，NPI-Q平均产生的灵敏度为74.1%，特异度为79.5%。在NPI-Q上，信息提供者往往对症状较轻的患者过度报告症状，但随着症状严重程度增加而少报。NPI-Q的内部一致性是可接受的（Cronbach's α = 0.756）。NPI-Q的一周重测信度极佳（组内相关系数 = 0.990）。NPI-Q是筛查中风和TIA患者神经精神症状的有效且可靠的工具。

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