Bernhard Yann, Collin Bertrand, Decréau Richard A
Institut de Chimie Moléculaire de l'Université de Bourgogne (ICMUB), UMR 6302 CNRS-Université de Bourgogne, BP 47870, F-21078, Dijon Cedex, France.
Chem Commun (Camb). 2014 Jun 28;50(51):6711-3. doi: 10.1039/c4cc01690d.
The Cherenkov radiation (CR) from [(18)F]-FDG, [(177)Lu]-LuCl3 and [(90)Y]-YCl3 was detected and CR energy transfer (CRET) to several fluorophores was examined. Subsequent fluorescence emission was found to be a function of the position of absorption bands with respect to the CR peak, energy of emitted particles, radionuclide/fluorophore loading, and fluorophore brightness. A variant of the best fluorophore with a built-in radionuclide was synthesized to achieve inter- and intra-molecular CRET.
检测了[(18)F]-FDG、[(177)Lu]-LuCl3和[(90)Y]-YCl3产生的切伦科夫辐射(CR)，并研究了CR向几种荧光团的能量转移(CRET)。结果发现，随后的荧光发射是吸收带相对于CR峰值的位置、发射粒子的能量、放射性核素/荧光团负载量以及荧光团亮度的函数。合成了一种内置放射性核素的最佳荧光团变体，以实现分子间和分子内的CRET。
