Nowrangi Milap A, Lyketsos Constantine, Rao Vani, Munro Cynthia A
J Neuropsychiatry Clin Neurosci. 2014 Apr 1;26(2):114-25. doi: 10.1176/appi.neuropsych.12070176.
Executive functioning (EF) is an important cognitive domain that is negatively affected in a number of neuropsychiatric conditions. Neuroimaging methods have led to insights into the anatomical and functional nature of EF. The authors conducted a systematic review of the recent cognitive and neuroimaging literature to investigate how the neuroimaging correlates of EF compare between different diagnostic groups. The authors found that the frontal, parietal, and cerebellar lobes were most frequently associated with EF when comparing results from different clinical populations; the occipital lobe was not correlated with EF in any group. These findings suggest that individual disease processes affect circuits within an identifiable distributed network rather than isolated regions.
执行功能(EF)是一个重要的认知领域,在许多神经精神疾病中会受到负面影响。神经影像学方法使人们对执行功能的解剖学和功能本质有了深入了解。作者对最近的认知和神经影像学文献进行了系统综述,以研究不同诊断组之间执行功能的神经影像学相关性如何比较。作者发现,在比较不同临床人群的结果时,额叶、顶叶和小脑叶与执行功能的关联最为频繁;枕叶在任何组中都与执行功能无关。这些发现表明,个体疾病过程会影响一个可识别的分布式网络中的回路,而不是孤立的区域。