Lv Cheng-Yu, Zhou Tao, Chen Wei, Yin Xin-Dao, Yao Jian-Hong, Zhang Yi-Fan
Cheng-Yu Lv, Tao Zhou, Wei Chen, Xin-Dao Yin, Jian-Hong Yao, Yi-Fan Zhang, Department of General Surgery, Nanjing Hospital Affiliated to Nanjing Medical University, Nanjing 210006, Jiangsu Province, China.
World J Gastroenterol. 2014 Apr 21;20(15):4428-32. doi: 10.3748/wjg.v20.i15.4428.
To study the relationship between the CX3CL1 chemokine, its receptor CX3CR1, and gastric carcinoma/gastric carcinoma perineural invasion (PNI).
Thirty cases of gastric carcinoma were surgically resected (radical resection or palliative resection) between February 2012 and July 2012. Tumour and tumour-adjacent tissues were evaluated for the presence of CX3CL1 (ELISA) and CX3CR1 (immunohistochemistry and Western blotting) in an effort to analyse the relationship between CX3CL1/CX3CR1 and gastric carcinoma/gastric carcinoma PNI.
Of these 30 cases, 14 were PNI-positive (46.7%). No significant differences in CX3CL and CX3CR1 expression in tumour-adjacent tissues were found between the PNI positive and negative groups. Expression levels of CX3CL and CX3CR1 in tumour tissues were significantly higher than those in adjacent tissues (P < 0.01), and were significantly higher in tumour tissues from the PNI-positive group compared to the PNI-negative group (P < 0.01).
CX3CL1/CX3CR1 expression may be associated with the occurrence and development of gastric carcinoma as well as gastric carcinoma PNI.
研究趋化因子CX3CL1及其受体CX3CR1与胃癌及胃癌神经周围浸润（PNI）之间的关系。
选取2012年2月至2012年7月间手术切除（根治性切除或姑息性切除）的30例胃癌病例。通过酶联免疫吸附测定法（ELISA）检测肿瘤及肿瘤旁组织中CX3CL1的表达情况，采用免疫组织化学和蛋白质免疫印迹法检测CX3CR1的表达情况，以分析CX3CL1/CX3CR1与胃癌及胃癌PNI之间的关系。
这30例病例中，14例为PNI阳性（46.7%）。PNI阳性组和阴性组的肿瘤旁组织中CX3CL和CX3CR1表达无显著差异。肿瘤组织中CX3CL和CX3CR1的表达水平显著高于相邻组织（P < 0.01），且PNI阳性组肿瘤组织中的表达水平显著高于PNI阴性组（P < 0.01）。
CX3CL1/CX3CR1表达可能与胃癌的发生发展以及胃癌PNI有关。
