采用统一放疗计划行根治性同期放化疗治疗食管和下咽局部同步鳞状细胞癌。
Localized synchronous squamous cell carcinomas of the esophagus and hypopharynx treated with definitive concurrent chemoradiotherapy with a unified radiotherapy plan.
机构信息
Department of Radiation Oncology, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY, U.S.A.
出版信息
Curr Oncol. 2014 Apr;21(2):e354-7. doi: 10.3747/co.21.1844.
Abstract
Because of common risk factors, synchronous squamous cell carcinomas of the esophagus and head and neck are common, and their concurrent presence can significantly complicate disease eradication and survival. Here, we report the case of a patient with a history of extensive tobacco and alcohol use who was diagnosed with a localized thoracic esophageal squamous cell carcinoma, and in whom positron-emission tomography-computed tomography discovered a nearby asymptomatic localized hypopharyngeal focus that was confirmed by biopsy to also be malignant. He was treated with definitive concurrent chemoradiotherapy in a single unified radiotherapy plan, with surgery reserved for salvage treatment. He currently remains in remission without a need for surgical salvage. However, significant concern remains for both treatment failure and development of another primary because of "field cancerization."
摘要
由于共同的危险因素，食管和头颈部的同时性鳞状细胞癌很常见，它们的同时存在会显著增加疾病根除和生存的难度。在这里，我们报告了一例有广泛吸烟和饮酒史的患者，该患者被诊断为局限性胸段食管鳞状细胞癌，正电子发射断层扫描-计算机断层扫描（PET-CT）发现附近有一处无症状的局限性下咽病灶，活检证实也为恶性。他接受了根治性同步放化疗，采用单一的统一放疗计划，保留手术作为挽救治疗。他目前仍处于缓解状态，无需手术挽救。然而，由于“癌化场”，对治疗失败和另一个原发性肿瘤的发展仍存在很大的担忧。
相似文献
1
Localized synchronous squamous cell carcinomas of the esophagus and hypopharynx treated with definitive concurrent chemoradiotherapy with a unified radiotherapy plan.采用统一放疗计划行根治性同期放化疗治疗食管和下咽局部同步鳞状细胞癌。
Curr Oncol. 2014 Apr;21(2):e354-7. doi: 10.3747/co.21.1844.
2
Impact of the early detection of esophageal neoplasms in hypopharyngeal cancer patients treated with concurrent chemoradiotherapy.下咽癌患者同步放化疗时食管肿瘤早期检测的影响
Asia Pac J Clin Oncol. 2017 Apr;13(2):e3-e10. doi: 10.1111/ajco.12274. Epub 2014 Oct 31.
3
Association of multiple Lugol-voiding lesions with synchronous and metachronous esophageal squamous cell carcinoma in patients with head and neck cancer.头颈部癌患者中多个不染碘病变与同步及异时性食管鳞状细胞癌的关联
Gastrointest Endosc. 2002 Oct;56(4):517-21. doi: 10.1067/mge.2002.128104.
4
Salvage esophagectomy after definitive chemoradiotherapy for synchronous double cancers of the esophagus and head-and-neck.根治性放化疗后同步性食管和头颈部双原发癌的挽救性食管切除术。
Dis Esophagus. 2010 Jan;23(1):59-63. doi: 10.1111/j.1442-2050.2009.00973.x. Epub 2009 Apr 15.
5
The effectiveness of chemoradiation therapy and salvage surgery for hypopharyngeal squamous cell carcinoma.化放疗法和挽救性手术治疗下咽鳞状细胞癌的效果。
Jpn J Clin Oncol. 2013 Dec;43(12):1210-7. doi: 10.1093/jjco/hyt136. Epub 2013 Sep 12.
6
Treatment results and prognostic factors for advanced squamous cell carcinoma of the head and neck treated with salvage surgery after concurrent chemoradiotherapy.同步放化疗后挽救性手术治疗晚期头颈部鳞状细胞癌的治疗结果及预后因素
Int J Clin Oncol. 2016 Oct;21(5):869-874. doi: 10.1007/s10147-016-0964-2. Epub 2016 Feb 23.
7
Neoadjuvant concurrent chemoradiotherapy followed by definitive high-dose radiotherapy or surgery for operable thoracic esophageal carcinoma.新辅助同步放化疗后行根治性高剂量放疗或手术治疗可切除的胸段食管癌。
Int J Radiat Oncol Biol Phys. 1998 Mar 15;40(5):1049-59. doi: 10.1016/s0360-3016(97)00900-0.
8
Salvage radiotherapy for recurrent hypopharyngeal and laryngeal squamous cell carcinoma (SCC) after first-line treatment with surgery alone: a 10-year single-centre experience.根治性放疗治疗单纯手术一线治疗后复发的下咽及喉鳞状细胞癌：10 年单中心经验。
Radiat Oncol. 2019 Feb 19;14(1):34. doi: 10.1186/s13014-019-1238-8.
9
Use of transnasal endoscopy for screening of esophageal squamous cell carcinoma in high-risk patients: yield rate, completion rate, and safety.经鼻内镜用于高危患者食管鳞癌筛查：检出率、完成率和安全性。
Dig Endosc. 2014 Jan;26(1):24-31. doi: 10.1111/den.12053. Epub 2013 Mar 31.
10
[Comparative analysis of clinical efficacies between induction chemotherapy and surgery combined with radiotherapy or concurrent chemoradiotherapy in advanced hypopharyngeal carcinoma].[诱导化疗与手术联合放疗或同步放化疗治疗晚期下咽癌的临床疗效对比分析]
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Dec 7;53(12):918-924. doi: 10.3760/cma.j.issn.1673-0860.2018.12.009.
引用本文的文献
1
Simultaneous concurrent chemoradiotherapy and esophagectomy for synchronous head and neck and esophageal squamous cell carcinoma: a retrospective review.同步放化疗与食管切除术治疗同步性头颈部和食管鳞状细胞癌：一项回顾性研究。
Radiat Oncol. 2025 Jul 9;20(1):107. doi: 10.1186/s13014-025-02681-0.
2
Treatment of Squamous Cell Carcinoma of the Esophagus Synchronously Associated with Head and Neck Cancer.同步合并头颈部癌的食管鳞状细胞癌的治疗
In Vivo. 2017 Sep-Oct;31(5):909-916. doi: 10.21873/invivo.11146.
3
Clinical outcomes of synchronous head and neck and esophageal cancer.同步性头颈部和食管癌的临床结局
Radiat Oncol J. 2015 Sep;33(3):172-8. doi: 10.3857/roj.2015.33.3.172. Epub 2015 Sep 30.
4
Efficacy of Staged Treatment Strategy for Patients with Synchronous Double Cancers of the Esophagus and Head and Neck: A Retrospective Study.同步性食管与头颈部双原发癌患者分期治疗策略的疗效：一项回顾性研究
World J Surg. 2016 Feb;40(2):388-94. doi: 10.1007/s00268-015-3276-1.
5
Xenogeneic acellular dermal matrix in combination with pectoralis major myocutaneous flap reconstructs hypopharynx and cervical esophagus.异种脱细胞真皮基质联合胸大肌肌皮瓣重建下咽及颈段食管。
Eur Arch Otorhinolaryngol. 2015 Nov;272(11):3457-61. doi: 10.1007/s00405-014-3355-1. Epub 2014 Oct 31.
本文引用的文献
1
Trends over three decades of the risk of second primary cancer among patients with head and neck cancer.头颈部癌症患者 30 多年来第二原发癌风险的趋势。
Oral Oncol. 2013 Jan;49(1):9-14. doi: 10.1016/j.oraloncology.2012.06.018. Epub 2012 Jul 26.
2
Preoperative chemoradiotherapy for esophageal or junctional cancer.术前放化疗治疗食管或食管胃交界癌。
N Engl J Med. 2012 May 31;366(22):2074-84. doi: 10.1056/NEJMoa1112088.
3
Population attributable risk of tobacco and alcohol for upper aerodigestive tract cancer.上呼吸道和消化道癌症的烟草和酒精归因风险人群。
Oral Oncol. 2011 Aug;47(8):725-31. doi: 10.1016/j.oraloncology.2011.05.004.
4
Synchronous second primary tumors in 2,016 head and neck cancer patients: role of symptom-directed panendoscopy.2016 例头颈部癌症患者的同步第二原发肿瘤：症状导向全内镜检查的作用。
Laryngoscope. 2011 Feb;121(2):304-9. doi: 10.1002/lary.21385.
5
Risk factors for developing synchronous esophageal neoplasia in patients with head and neck cancer.头颈部癌症患者发生食管同步肿瘤的风险因素。
Head Neck. 2011 Jan;33(1):77-81. doi: 10.1002/hed.21397.
6
Tobacco smoking during radiation therapy for head-and-neck cancer is associated with unfavorable outcome.头颈部癌症放射治疗期间吸烟与不良结局相关。
Int J Radiat Oncol Biol Phys. 2011 Feb 1;79(2):414-9. doi: 10.1016/j.ijrobp.2009.10.050. Epub 2010 Apr 14.
7
Low prevalence of submucosal invasive carcinoma at esophagectomy for high-grade dysplasia or intramucosal adenocarcinoma in Barrett's esophagus: a 20-year experience.巴雷特食管高级别异型增生或黏膜内腺癌食管切除术中黏膜下浸润癌的低发生率：20年经验
Gastrointest Endosc. 2009 Apr;69(4):777-83. doi: 10.1016/j.gie.2008.05.013. Epub 2009 Jan 10.
8
Trends in incidence and prognosis for head and neck cancer in the United States: a site-specific analysis of the SEER database.美国头颈癌的发病率和预后趋势：监测、流行病学和最终结果（SEER）数据库的特定部位分析
Int J Cancer. 2005 May 1;114(5):806-16. doi: 10.1002/ijc.20740.
9
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer.同步放化疗用于晚期喉癌的器官保留治疗
N Engl J Med. 2003 Nov 27;349(22):2091-8. doi: 10.1056/NEJMoa031317.
10
Clinical analysis of multiple primary malignancies of the hypopharynx and esophagus.下咽和食管多原发性恶性肿瘤的临床分析
Am J Otolaryngol. 2001 Mar-Apr;22(2):107-10. doi: 10.1053/ajot.2001.22566.
Zotero 插件