Department of Radiation Oncology, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY, U.S.A.
Curr Oncol. 2014 Apr;21(2):e354-7. doi: 10.3747/co.21.1844.
Because of common risk factors, synchronous squamous cell carcinomas of the esophagus and head and neck are common, and their concurrent presence can significantly complicate disease eradication and survival. Here, we report the case of a patient with a history of extensive tobacco and alcohol use who was diagnosed with a localized thoracic esophageal squamous cell carcinoma, and in whom positron-emission tomography-computed tomography discovered a nearby asymptomatic localized hypopharyngeal focus that was confirmed by biopsy to also be malignant. He was treated with definitive concurrent chemoradiotherapy in a single unified radiotherapy plan, with surgery reserved for salvage treatment. He currently remains in remission without a need for surgical salvage. However, significant concern remains for both treatment failure and development of another primary because of "field cancerization."
由于共同的危险因素，食管和头颈部的同时性鳞状细胞癌很常见，它们的同时存在会显著增加疾病根除和生存的难度。在这里，我们报告了一例有广泛吸烟和饮酒史的患者，该患者被诊断为局限性胸段食管鳞状细胞癌，正电子发射断层扫描-计算机断层扫描（PET-CT）发现附近有一处无症状的局限性下咽病灶，活检证实也为恶性。他接受了根治性同步放化疗，采用单一的统一放疗计划，保留手术作为挽救治疗。他目前仍处于缓解状态，无需手术挽救。然而，由于“癌化场”，对治疗失败和另一个原发性肿瘤的发展仍存在很大的担忧。
