Nuclear Science & Technology Development Center and ‡Department of Chemistry, National Tsing Hua University , Hsinchu 30013, Taiwan.
ACS Appl Mater Interfaces. 2014 May 28;6(10):7198-203. doi: 10.1021/am500324z. Epub 2014 May 6.
An efficient method for modifying the surface of detonation nanodiamonds (5 and 100 nm) with thiol groups (-SH) by using an organic chemistry strategy is presented herein. Thiolated nanodiamonds were characterized by spectroscopic techniques, and the atomic percentage of sulfur was analyzed by elemental analysis and X-ray photoelectron spectroscopy. The conjugation between thiolated nanodiamonds and gold nanoparticles was elucidated by transmission electron microscopy and UV-vis spectrometry. Moreover, the material did not show significant cytotoxicity to the human lung carcinoma cell line and may prospectively be applied in bioconjugated technology. The new method that we elucidated may significantly improve the approach to surface modification of detonation nanodiamonds and build up a new platform for the application of nanodiamonds.
本文提出了一种通过有机化学策略高效地在爆轰纳米金刚石（5nm 和 100nm）表面修饰巯基（-SH）的方法。采用光谱技术对巯基化纳米金刚石进行了表征，并通过元素分析和 X 射线光电子能谱分析了硫的原子百分比。通过透射电子显微镜和紫外-可见光谱阐明了巯基化纳米金刚石与金纳米粒子的键合。此外，该材料对人肺癌细胞系没有明显的细胞毒性，可能有望应用于生物偶联技术。我们阐明的新方法可能会显著改善爆轰纳米金刚石的表面修饰方法，并为纳米金刚石的应用建立一个新的平台。
