Sehgal Virendra N, Riyaz Najeeba, Chatterjee Kingshuk, Venkatash Pradeep, Sharma Sonal
Dermato-Venereology (Skin/VD) Center, Sehgal Nursing Home, A/6 Panchwati, Delhi-110 033, India.
Department of Dermatology Govt Medical College, Calicut, India.
Clin Dermatol. 2014 May-Jun;32(3):351-63. doi: 10.1016/j.clindermatol.2013.11.002. Epub 2013 Nov 23.
Sarcoidosis is a systemic disease, where for the abnormal localized collections of chronic inflammatory cells, the granuloma is cardinal, which may result in the formation of nodule(s) in the tissue of any organ of the body, with lungs and lymph nodes involvement being the most common. The granulomas are nonnecrotizing. The disease may either be asymptomatic or chronic. Its onset is gradual and may improve or clear up spontaneously. Clinical features of specific and nonspecific cutaneous lesions are described, emphasizing their role as a prelude to its systemic manifestations, afflicting respiratory, liver, spleen, musculoskeletal, ocular, cardiac, and neurologic systems. The salient briefs of diagnostic procedures are outlined, in addition to historical background and etiopathogenesis. Several currently available treatment modalities are outlined for instant reference.
结节病是一种全身性疾病，其主要特征是慢性炎症细胞异常局部聚集形成肉芽肿，这可能导致身体任何器官组织中出现结节，其中肺部和淋巴结受累最为常见。这些肉芽肿是非坏死性的。该疾病可能无症状或呈慢性。其起病隐匿，可能会自行改善或消退。文中描述了特异性和非特异性皮肤病变的临床特征，强调了它们作为全身表现前奏的作用，全身表现会累及呼吸、肝脏、脾脏、肌肉骨骼、眼部、心脏和神经系统。除了历史背景和病因发病机制外，还概述了诊断程序的要点。文中还概述了几种目前可用的治疗方法以供即时参考。
