视网膜色素变性患者的视网膜血管血氧饱和度及血管直径
Retinal vessel oxygen saturation and vessel diameter in retinitis pigmentosa.
作者信息
Eysteinsson Thor, Hardarson Sveinn H, Bragason David, Stefánsson Einar
机构信息
Physiology, University of Iceland, Reykjavik, Iceland; Ophthalmology, University of Iceland/Landspitali University Hospital, Reykjavik, Iceland.
出版信息
Acta Ophthalmol. 2014 Aug;92(5):449-53. doi: 10.1111/aos.12359. Epub 2014 Apr 27.
PURPOSE
To assess retinal vessel oxygen saturation and retinal vessel diameter in retinitis pigmentosa.
METHODS
A retinal oximeter (Oxymap ehf., Reykjavik, Iceland) was used to measure retinal vessel oxygen saturation and vessel diameter in ten patients with retinitis pigmentosa (RP) (mean age 49 years, range 23-71 years). Results were compared with age- and gender-matched healthy individuals. All patients had advanced stage of the disease with visual fields restricted to the macular region.
RESULTS
Oxygen saturation in retinal venules was 58.0 ± 6.2% in patients with RP and 53.4 ± 4.8% in healthy subjects (p = 0.017). Oxygen saturation in retinal arterioles was not significantly different between groups (p = 0.65). The mean diameter of retinal arterioles was 8.9 ± 1.6 pixels in patients with RP and 11.4 ± 1.2 in healthy controls (p < 0.0001). The corresponding diameters for venules were 10.1 ± 1.2 (RP) and 15.3 ± 1.7 (healthy, p < 0.0001).
CONCLUSIONS
Increased venous saturation and decreased retinal vessel diameter suggest decreased oxygen delivery from the retinal circulation in retinitis pigmentosa. This is probably secondary to tissue atrophy and reduced oxygen consumption.
目的
评估色素性视网膜炎患者的视网膜血管血氧饱和度及视网膜血管直径。
方法
使用视网膜血氧仪（Oxymap ehf.，冰岛雷克雅未克）测量10例色素性视网膜炎（RP）患者（平均年龄49岁，范围23 - 71岁）的视网膜血管血氧饱和度及血管直径。将结果与年龄和性别匹配的健康个体进行比较。所有患者均处于疾病晚期，视野局限于黄斑区。
结果
RP患者视网膜小静脉的血氧饱和度为58.0±6.2%，健康受试者为53.4±4.8%（p = 0.017）。两组之间视网膜小动脉的血氧饱和度无显著差异（p = 0.65）。RP患者视网膜小动脉的平均直径为8.9±1.6像素，健康对照组为11.4±1.2像素（p < 0.0001）。小静脉的相应直径分别为10.1±1.2（RP）和15.3±1.7（健康，p < 0.0001）。
结论
静脉血氧饱和度升高及视网膜血管直径减小表明色素性视网膜炎患者视网膜循环的氧输送减少。这可能继发于组织萎缩和氧消耗减少。
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