Wang Henry E, Baddley John, Griffin Russell L, Judd Suzanne, Howard George, Donnelly John P, Safford Monika M
Department of Emergency Medicine, University of Alabama School of Medicine, USA.
Division of Infectious Diseases, Department of Medicine, University of Alabama School of Medicine, USA.
Prev Med. 2014 Aug;65:58-64. doi: 10.1016/j.ypmed.2014.04.017. Epub 2014 Apr 24.
The authors sought to determine the association between physical inactivity (characterized by exercise and television watching levels) and long-term rates of community-acquired sepsis.
The study utilized a population-based cohort of 30,183 adult (≥45 years) community dwelling adults. Subjects reported weekly exercise (low=none, medium=1-3times/week, high=≥4times/week) and daily television watching (low=<1h/day, medium=1-3h/day, high=≥4h/day) levels. The authors evaluated the association between exercise, television watching and rates of sepsis, defined as hospital treatment for a serious infection with ≥2 Systemic Inflammatory Response Syndrome (SIRS) criteria.
Among 30,183 participants, 1500 experienced a sepsis event. Reported weekly exercise was: high 8798 (29.2%), medium 10,695 (35.4%), and low 10,240 (33.9%). Where available, reported daily television watching was: low 4615 (19.6%), medium 11,587 (49.3%) and high 7317 (31.1%). Decreased weekly exercise was associated with increased adjusted sepsis rates (high - referent; medium - HR 1.02, 95% CI 0.96-1.20; low - 1.33, 1.13-1.56). Daily television watching was not associated with sepsis rates. Sepsis rates were highest among those with both low exercise and high television watching levels (HR 1.49, 95% CI: 1.10-2.01).
Physical inactivity may be associated with increased long-term rates of community-acquired sepsis.
作者试图确定身体活动不足（以运动和看电视水平为特征）与社区获得性败血症的长期发生率之间的关联。
该研究使用了一个基于人群的队列，其中包括30183名成年（≥45岁）社区居住成年人。受试者报告了每周的运动情况（低=无，中=每周1 - 3次，高=每周≥4次）和每天看电视的情况（低=每天<1小时，中=每天1 - 3小时，高=每天≥4小时）。作者评估了运动、看电视与败血症发生率之间的关联，败血症定义为因严重感染接受住院治疗且符合≥2条全身炎症反应综合征（SIRS）标准。
在30183名参与者中，有1500人发生了败血症事件。报告的每周运动情况为：高8798人（29.2%），中10695人（35.4%），低10240人（33.9%）。在可获得数据的情况下，报告的每天看电视情况为：低4615人（19.6%），中11587人（49.3%），高7317人（31.1%）。每周运动减少与调整后的败血症发生率增加相关（高 - 参照组；中 - 风险比1.02，95%置信区间0.96 - 1.20；低 - 1.33，1.13 - 1.56）。每天看电视与败血症发生率无关。在运动少且看电视多的人群中，败血症发生率最高（风险比1.49，95%置信区间：1.10 - 2.01）。
身体活动不足可能与社区获得性败血症的长期发生率增加有关。
