Bayin Nermin Sumru, Modrek Aram Sandaldjian, Placantonakis Dimitris George
Nermin Sumru Bayin, Aram Sandaldjian Modrek, Dimitris George Placantonakis, Department of Neurosurgery, New York University School of Medicine, New York, NY 10016, United States.
World J Stem Cells. 2014 Apr 26;6(2):230-8. doi: 10.4252/wjsc.v6.i2.230.
Glioblastoma Multiforme (GBM) is a grade IV astrocytoma, with a median survival of 14.6 mo. Within GBM, stem-like cells, namely glioblastoma stem cells (GSCs), have the ability to self-renew, differentiate into distinct lineages within the tumor and initiate tumor xenografts in immunocompromised animal models. More importantly, GSCs utilize cell-autonomous and tumor microenvironment-mediated mechanisms to overcome current therapeutic approaches. They are, therefore, very important therapeutic targets. Although the functional criteria defining GSCs are well defined, their molecular characteristics, the mechanisms whereby they establish the cellular hierarchy within tumors, and their contribution to tumor heterogeneity are not well understood. This review is aimed at summarizing current findings about GSCs and their therapeutic importance from a molecular and cellular point of view. A better characterization of GSCs is crucial for designing effective GSC-targeted therapies.
多形性胶质母细胞瘤（GBM）是一种IV级星形细胞瘤，中位生存期为14.6个月。在GBM中，干细胞样细胞，即胶质母细胞瘤干细胞（GSCs），具有自我更新能力，可在肿瘤内分化为不同谱系，并在免疫缺陷动物模型中引发肿瘤异种移植。更重要的是，GSCs利用细胞自主和肿瘤微环境介导的机制来克服当前的治疗方法。因此，它们是非常重要的治疗靶点。尽管定义GSCs的功能标准已明确，但它们分子特征、在肿瘤内建立细胞层次结构的机制以及它们对肿瘤异质性的贡献仍未得到充分了解。本综述旨在从分子和细胞角度总结关于GSCs及其治疗重要性的当前研究结果。更好地表征GSCs对于设计有效的GSC靶向治疗至关重要。
